2024-01-242024-01-242021-09Kural, S. vd. (2021). "Characteristics of early-onset vs late-onset colorectal cancer a review". JAMA Surgery, 156(9), 865-874.2168-62542168-6262https://jamanetwork.com/journals/jamasurgery/article-abstract/2781485https://hdl.handle.net/11452/39289Çalışmada 221 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. Observations: Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. Conclusions and Relevance: The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.eninfo:eu-repo/semantics/closedAccessLynch syndromeIncreasing incidenceGut microbiotaRectal-cancerUnited-statesYoung-adultsRiskAgeAdenocarcinomaFeaturesAdultAge of onsetColorectal neoplasmsHumansIncidenceMiddle agedRisk factorsArticle0006690190000052-s2.0-85114982910865874156934190968https://doi.org/10.1001/jamasurg.2021.2380SurgeryColon Tumor; Colorectal Neoplasms; Colloid CarcinomaAntibiotic agentAdvanced cancerCancer adjuvant therapyCancer epidemiologyCancer riskCancer screeningClinical featureClinical outcomeColorectal cancerDescending colonEarly cancerEmbaseExposomeGenetic predispositionGermline mutationHereditary tumor syndromeHistopathologyHumanIntestine floraLate onset disorderMedical literatureMedlineNeoadjuvant therapyObesityOnset ageReviewScopusSomatic mutationWestern dietAdultColorectal tumorIncidenceMiddle agedPathologyRisk factor