Besli, FeyzullahKecebas, MesutTurker, Yasin2023-10-022023-10-022015-05-01Besli, F. vd. (2015). "The utility of inferior vena cava diameter and the degree of inspiratory collapse in patients with systolic heart failure". American Journal of Emergency Medicine, 33(5), 653-657.https://doi.org/10.1016/j.ajem.2015.02.006http://hdl.handle.net/11452/34182Introduction: Both inferior vena cava (IVC) diameter and the degree of inspiratory collapse are used in the estimation of right atrial pressure. Aim: The purpose of this study is to evaluate the utility of IVC diameter, using echocardiography as a marker of volume overload and the relationship between these parameters and N-terminal pro-B natriuretic peptide (NT-proBNP) in patients with systolic heart failure (HF). Methods: We included 136 consecutive patients with systolic HF (left ventricular ejection fraction, <50%), including 80 patients with acutely decompensated HF and 56 patients with compensated HF as well as 50 subjects without a diagnosis of HF. All patients underwent transthoracic echocardiography to assess both their IVC diameters and the degree of inspiratory collapse (>= 50%, <50%, and no change [absence] groups); NT-proBNP levels were measured, and these data were compared between the 2 groups. Results: Inferior vena cava diameter and NT-proBNP were significantly higher among the patients with HF than among the control subjects (21.7 +/- 2.6 vs 14.5 +/- 1.6 mm, P < .001 and 4789 [330-35000] vs 171 [21-476], P < .001). The mean IVC diameter was higher among the patients with decompensated HF than among the patients with compensated HF (23.2 +/- 2.1 vs 19.7 +/- 1.9 mm, P < .001). The values of NT-proBNP were associated with different collapsibility of IVC subgroups among HF patients. The NT-proBNP levels were 2760 (330-27336), 5400 (665-27210), and 16806 (1786-35000), regarding the collapsibility of the IVC subgroups: greater than or equal to 50%, less than 50%, and absence groups, P < .001, respectively, among HF patients. There was a significant positive correlation between IVC diameter and NT-proBNP (r = 0.884, P < .001). A cut off value of an IVC diameter greater than or equal to 20.5 mm predicted a diagnosis of compensated HF with a sensitivity of 90% and a specificity of 73%. Conclusions: Inferior vena cava diameter correlated significantly with NT-proBNP in patients with HF. Inferior vena cava diameter may be a useful variable in determining a patient's volume status in the setting of HF and may also enable clinicians to distinguish patients with decompensated HF from those with compensated HF.eninfo:eu-repo/semantics/closedAccessNatriuretic peptideEmergency-departmentPhysical-examinationAtrial pressureEchocardiographyUltrasoundAssociationDyspneaEmergency medicineBiological markersEchocardiographyFemaleHeart failure, systolicHumansInhalationMaleMiddle agedNatriuretic peptide, brainPeptide fragmentsSensitivity and specificityVena cavaInferiorArticle0003542916000102-s2.0-8492927698665365733525704186Emergency medicineBrain natriuretic peptide; Heart failure; BiomarkersAmino terminal pro brain natriuretic peptideBiological markerBrain natriuretic peptidePeptide fragmentPro-brain natriuretic peptide (1-76)Acute heart failureAdultAgedArticleCollapseControlled studyFemaleHeart left ventricle ejection fractionHeart left ventricle overloadHeart right atrium pressureHumanInferior cava veinInspiratory collapseMajor clinical studyMalePiority journalSensitivity and specificitySystolic heart failureTransthoracic echocardiographyVein diameterBloodEchocardiographyEchographyInferior cava veinInhalationMiddle agedSystolic heart failure