2023-05-172023-05-172013-12-04Bağdaş, D. vd. (2013). “Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain”. Neuroreport, 24(17), 941-946.0959-49651473-558Xhttps://doi.org/10.1097/WNR.0000000000000009http://hdl.handle.net/11452/32700Recent studies have demonstrated that arginine vasopressin (AVP) plays a crucial role in pain modulation. In addition, our previous studies have proven that centrally administered cytidine-5-diphosphate-choline (CDP-choline; citicoline) elicits an analgesic effect in different pain models in rats. Given that CDP-choline enhances central and peripheral vasopressin levels, the present study was designed to investigate the role of central AVP receptors in the analgesic effect of CDP-choline in acute and chronic constriction injury-induced neuropathic pain models. For this purpose, rats were pretreated intracerebroventricularly with the AVP V-1 or AVP V-2 receptor antagonist 15 min before intracerebroventricular injection of CDP-choline or saline, and pain threshold was determined using the Randall-Selitto test. AVP V-1 and AVP V-2 receptor antagonist blocked the CDP-choline-induced analgesic effect either in acute or neuropathic models of pain in rats. These results suggest, for the first time, that central AVP receptors are involved in the CDP-choline-elicited analgesic effect.eninfo:eu-repo/semantics/closedAccessNeurosciences & neurologyAcute painAnalgesiaArginine vasopressinCDP-cholineNeuropathic painPeriaqueductal grayAntinociceptionRatInvolvementNociceptionNucleiModelsAcute painAnalgesicsAnimalsArginine vasopressinBrainCytidine diphosphate cholineMaleNeuralgiaPain measurementPain thresholdRatsRats, Sprague-DawleyReceptors, vasopressinArticle0003265828000022-s2.0-84887096620941946241724089014NeurosciencesPain; Atosiban; VasopressinsArgipressin receptorCiticolineAnalgesic activityAnimal experimentAnimal modelAntinociceptionArticleControlled studyMaleNerve ligationNeuropathic painNonhumanPain thresholdPriority journalRat