2022-07-042022-07-042010-10Eryılmaz, S. vd. (2010). "Continuous positive airway pressure therapy improves arterial elasticity in patients with obstructive sleep apnea". Respiratory Medicine, 104(10), 1571-1576.0954-61111532-3064https://doi.org/10.1016/j.rmed.2010.05.002https://www.sciencedirect.com/science/article/pii/S0954611110002167http://hdl.handle.net/11452/27648Background: Reduced arterial elasticity is an important mediator of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). The aim of our study was to investigate whether continuous positive airway pressure (CPAP) therapy may improve arterial elasticity in subjects with OSA. Methods: In 44 subjects with OSA, we measured arterial elasticity by applanation tonometry before and after 6 months of treatment with CPAP. Nine OSA+ subjects withdrew from the study. Results: The 35 patients with OSA who completed the 6-month CPAP treatment showed a marked reduction in both the large artery (LAEI, P = 0.001) and small artery (SAEI, P = 0.009) elasticity indices, independent of potential confounders. In OSA+ subjects who withdrew from the study, SAEI and LAEI did not change significantly over time. Conclusions: Six months of CPAP therapy improves arterial elasticity in subjects with OSA.eninfo:eu-repo/semantics/openAccessObstructive sleep apnea syndromeEndothelial dysfunctionArterial elasticityContinuous positive airway pressurePulse-wave velocityEndothelial dysfunctionNitric-oxideStiffnessAtherosclerosisAssociationModerateCPAPCardiovascular system & cardiologyRespiratory systemArteriesContinuous positive airway pressureElasticityFemaleHumansMaleMiddle agedPolysomnographySleep apnea, obstructiveTime factorsTreatment outcomeArticle0002822473000242-s2.0-77956340887157115761041020570124Cardiac & cardiovascular systemsRespiratory systemObstructive Sleep Apnea; Positive End Expiratory Pressure; Pressure TreatmentArtery elasticityArticleCardiovascular riskClinical articleElasticityHumanPositive end expiratory pressurePriority journalSleep apnea syndromeTherapy effect