Kayır, HakanAlıcı, TevfikYıldırım, MuratUlusoy, Kemal GökhanCeyhan, MertÇelik, TurgayUzbay, Tayfun2022-03-212022-03-212008-10-31Kayır, H. vd. (2008). "Stimulus properties of venlafaxine in a conditioned taste aversion procedure". European Journal of Pharmacology, 596(1-3), 102-106.0014-29991879-071210.1016/j.ejphar.2008.08.015https://www.sciencedirect.com/science/article/pii/S0014299908008893http://hdl.handle.net/11452/25227Conditioned stimulus properties of venlafaxine are still unknown. In the present study, the discriminative stimulus properties of venlafaxine by using a conditioned taste aversion procedure were investigated. Swiss Webster mice were allowed to reach water from 2 pipettes for 20 min (09:00-11:30 h), plus 30 min (15:3016:00 h), daily. During the 4 days, the test drugs [fluoxetine, escitalopram, tianeptine, reboxetine, and N omega-nitro-L-arginine methyl ester(L-NAME)l were injected to mice at least 1 h after they had first water session. On day 5, they consumed glucose solution(5%w/v) and immediately injected with conditioning drug (venlafaxine 32 mg/kg). On day 8, mice were allowed to make a choice between water and glucose solution. The amount of glucose consumption as a percentage of total fluid intakes was calculated for each animal. Significant reduction in glucose choice was defined as conditioned taste aversion. Venlafaxine (32 mg/kg) induced a robust conditioned taste aversion in mice. Pre-exposure to tianeptine (2.5-10 mg/kg), fluoxetine (10 mg/kg), escitalopram (32 mg/kg), and reboxetine (5 mg/kg) substituted for venlafaxine by preventing the conditioned taste aversion induced by venlafaxine. L-NAME did not substitute for venlafaxine. Substitution of venlafaxine by fluoxetine, tianeptine, escitalopram, and reboxetine provides further evidence that both 5-HT and noradrenaline reuptake inhibition may play an important role in the stimulus effect of venlafaxine.eninfo:eu-repo/semantics/closedAccess(Mice)AntidepressantConditioned taste aversionEscitalopramFluoxetineI- nameReboxetineTianeptineVenlafaxineSerotonin reuptake inhibitorDiscriminative stimulusAntidepressantCitalopramDrugsPharmacology & pharmacyAdrenergic uptake inhibitorsAnimalsAntidepressive agentsAvoidance learningConditioning (psychology)CyclohexanolsMaleMiceNG-nitroarginine methyl esterNitric oxideNitric oxide synthaseSerotonin uptake inhibitorsTasteArticle0002604849000152-s2.0-530490986931021065961-318786528Pharmacology & pharmacyPsychedelic Agent; Serotonin 2A Receptor; LysergideEscitalopramFluoxetineGlucoseN(g) nitroarginine methyl esterNoradrenalinReboxetineSerotoninTianeptineVenlafaxineAnimal behaviorAnimal experimentArticleControlled studyDose responseDrug discriminationDrug effectDrug mechanismDrug substitutionFluid intakeGlucose intakeInstrumental conditioningMaleMouseNeurotransmitter uptakeNonhumanPriority journalStimulus responseSwiss Webster mouseTaste aversion