Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation

Pirianov, Grisha G.Wood, Edward JohnMehmet, Hüseyin2021-09-032021-09-032003-07Ulukaya, E. vd. (2003). “Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation”. Cell Death and Differentiation, 10(7), 856-859.1350-9047https://doi.org/10.1038/sj.cdd.4401242https://www.nature.com/articles/4401242http://hdl.handle.net/11452/21658eninfo:eu-repo/semantics/openAccessBiochemistry & molecular biologyCell biologyCarcinoma-cellsRetinoic acidN-(4-hydroxyphenyl)retinamidePathwayAntineoplastic agentsApoptosisCaspase 9CaspasesCell line, tumorCytochromes cEnzyme activationFenretinideHumansJNK mitogen-activated protein kinasesMembrane potentialsMitochondriaMitogen-activated protein kinasesReceptors, retinoic acidSignal transductionFenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisationLetter0001836125000132-s2.0-003849409385685910712815470Biochemistry & molecular biologyCell biologyFenretinide; N-(4-Methoxyphenyl)Retinamide; NeuroblastomaAntineoplastic agentApoptotic protease activating factor 1Caspase 9Cytochrome cDNA fragmentEnzyme precursorFenretinideProtein p53Retinoic acid apoptosisCell survivalConcentration responseControlled studyCytosolDrug cytotoxicityElectron microscopyEnzyme activationFluorescence analysisHumanHuman cellLetterMembrane depolarizationMembrane potentialMitochondrial membraneMolecular dynamicsNick end labelingPriority journalProtein secretionSquamous cell carcinomaUltraviolet irradiationWestern blotting