2021-08-272021-08-272006Demiray, M. vd. (2006). ''Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: A prospective pilot study''. Cancer Investigation, 24(7), 669-676.0735-79071532-4192https://doi.org/10.1080/07357900600981307https://www.tandfonline.com/doi/full/10.1080/07357900600981307http://hdl.handle.net/11452/21548The M30-monoclonal antibody recognizes a neo-epitope of cytokeratin 18 which is formed after caspase-cleavage during apoptosis. Caspase-cleaved cytokeratin 18 is released from apoptotic cells into circulation. The aim of this study was to evaluate the relationship between M30-antigen level and chemotherapy response in neoadjuvant treatment of breast cancer. Forty-two patients with invasive breast carcinoma received 4 cycles of anthracycline based neoadjuvant chemotherapy. Serum samples were obtained for assessment of M30-antigen levels before the administration of first chemotherapy cycle (baseline), and then after 24 and 48 hours for determination of chemotherapy induced apoptosis. M30-antigen levels at 24 and 48 hours were found to be significantly higher than baseline (p < 0.001, p = 0.003, respectively). M30-antigen levels in responders showed statistically significant increases at 24 and 48 hours (p < 0.001; p = 0.004, respectively), while statistically significant increases were not observed in nonresponders. Percentage change of M30-antigen levels was significantly higher in responders than nonresponders at 24 hours (p = 0.020). In conclusion, our study revealed a significant relationship between increases of M30-antigen levels in serum and overall response to therapy.eninfo:eu-repo/semantics/closedAccessOncologyChemotherapyNeoadjuvantApoptosisBreast cancerM30Cytokeratin 18ApoptosisBreast cancerAssayExpressionProliferationTumorsPreoperative chemotherapyArticle0002422077000022-s2.0-3375153893966967624717118776OncologyKeratin-18; Caspases; Intermediate Filament Proteins