Başaranoğlu, Sevgen TanirKaraaslan, AyşeSali, EnesÇiftçi, ErginAydın, Zeynep Gökçe GayretliKocabaş, Bilge AldemirKaya, CemilBayturan, Semra SenKara, Soner SertanÇiftdoğan, Dilek YılmazÇay, ÜmmühanAktürk, Hacer GündoğduÇelik, MeldaÖzdemir, HalilSomer, AyperDiri, TijenYazar, Ahmet SamiSütçü, MuratTezer, HasanÖncel, Eda KaradağKara, ManolyaCelebi, SolmazParlakay, Aslınur ÖzkayaKarakaşlılar, SabahatArısoy, Emin SamiTanir, GönülKara, Tuğçe TuralDevrim, İlkerErat, TuğbaAykaç, KubraKaba, ÖzgeGüven, ŞirinYeşil, EdanurYılmaz, Ayşe TekinDurmuş, Sevgi YaşarÇaglar, İlknurGunay, FatihÖzen, MetehanDinleyici, Ener ÇağriKara, Ateş2024-11-252024-11-252023-03-18https://doi.org/10.1186/s12887-023-03939-whttps://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-023-03939-whttps://pmc.ncbi.nlm.nih.gov/articles/PMC10024443/https://hdl.handle.net/11452/48389BackgroundAntibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region.MethodsThe prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre.ResultsA result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect.ConclusionThis study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.eninfo:eu-repo/semantics/openAccessGut microbiotaImpactAntibiotic-associated diarrheaOutpatient clinicsAmoxicillin-clavulanateCephalosporinsPhenoxymethyl penicillinsMacrolidesScience & technologyLife sciences & biomedicinePediatricsArticle00095429650000523110.1186/s12887-023-03939-w1471-2431