2023-01-112023-01-112017-04-18Erkan, L. G. vd. (2017). ''The acute cardiorespiratory effects of centrally injected arachidonic acid; the mediation of prostaglandin E, D and F-2 alpha''. Respiratory Physiology and Neurobiology, 242, 117-124.1569-9048https://doi.org/10.1016/j.resp.2017.04.006https://www.sciencedirect.com/science/article/pii/S15699048163027741878-1519http://hdl.handle.net/11452/30372Arachidonic acid (AA), which is released from synaptic membrane phospholipid by neuroreceptor-initiated activation of phospholipase A(2), is abundant in the brain and works as a neurotransmitter and/or neuromodulator in the central nervous system. Recently we reported that centrally injected AA generated pressor and hyperventilation effects by activating thromboxane A(2) (TXA(2)) signaling pathway. The present study was designed to investigate the mediation of other metabolites of AA such as prostaglandin (PG) D, PGE and PGF(2 alpha), alongside TXA(2) in the AA-evoked cardiorespiratory effects in anaesthetized rats. Intracerebroventricular (i.c.v.) administration of AA caused pressor, bradycardic and hyperventilation responses by increasing pO(2) and decreasing pCO(2) in adult male anaesthetized Sprague Dawley rats. Pretreatment (i.c.v) with different doses of DP/EP prostanoid receptor antagonist, AH6809 or FP prostanoid receptor antagonist, PGF(2 alpha), dimethylamine partially blocked the cardiorespiratory and blood gas changes induced by AA. In conclusion, these data plainly report that central PGD, PGE or PGF(2 alpha) might mediate, at least partly, centrally administered AA-evoked cardiorespiratory and blood gas responses.eninfo:eu-repo/semantics/closedAccessPhysiologyRespiratory systemArachidonic acidHeart rateIntracerebroventricularMean blood pressurePartial carbon dioxide pressurePartial oxygen pressurePGDPGEPGF2αRespiratory minute ventilationRespiratory rateTidal volumeThromboxane signaling pathwayHemorrhaged hypotensive ratsPhospholipase a(2) activatorCentral histaminergic systemBreathing movementsCardiovascular regulationPeripheral mechanismsRespiratory systemNormotensive ratsFetal sheepAnimalsArachidonic acidBlood gas analysisBlood pressureCardiovascular agentsInfusions, intraventricularMaleProstaglandins D.Prostaglandins E.Prostaglandins F.Rats, sprague-dawleyReceptors, prostaglandinRespirationRespiratory system agentsThromboxane A2Time factorsXanthonesArticle0004035192000182-s2.0-8501829374011712424228445779PhysiologyRespiratory systemHistamine H4 Receptors; Thioperamide; Intracerebroventricular Drug Administration6 isopropoxy 9 oxo 2 xanthenecarboxylic acidArachidonic acidDimethylamineProstaglandin F2 alpha6-isopropoxy-9-oxoxanthene-2-carboxylic acidArachidonic acidCardiovascular agentProstaglandin D.Prostaglandin E.Prostaglandin F.Prostaglandin receptorRespiratory tract agentThromboxane A2Xanthone derivativeAdultAnimal experimentAnimal modelArticleBlood gasBradycardiaCarbon dioxide tensionCardiovascular effectControlled studyHyperventilationMaleNonhumanOxygen tensionPriority journalRatRespiratory functionAnimalAntagonists and inhibitorsBlood gas analysisBlood pressureBreathingDrug effectsIntracerebroventricular drug administrationMetabolismPhysiologySprague dawley ratTime factor