Yıldırım, Ayhan2024-07-022024-07-022020-03-161011-372Xhttps://doi.org/10.1007/s10562-020-03175-2https://link.springer.com/article/10.1007/s10562-020-03175-2https://hdl.handle.net/11452/42692The present work was undertaken to ascertain whether IL-metal salt catalyzed isopropylidenation of d-fructose yield desired acetonides. For the first time, an imidazole based ionic liquid compound accompanied with strontium chloride has been identified as a suitable dual catalyst system for the chemoselective O-isopropylidenation of d-fructose with acetone. In the present protocol, mainly the kinetically controlled less stable cyclic ketal 1,2;4,5-di-O-isopropylidene-beta-d-fructopyranose is formed as an initial product with satisfactory yield and without isomerization to the thermodynamically more stable cyclic ketal 2,3;4,5-di-O-isopropylidene-beta-d-fructopyranose. Therefore, this protocol is more advantageous compared to other mineral acid catalyzed protocols that require more sensitive reaction conditions.eninfo:eu-repo/semantics/closedAccessO-isopropylidenationChiral auxiliaryAcetonationSugarAcidDerivativesAcetalsIodineD-fructoseO-isopropylidenationIonic liquidChemoselectiveAcetonationScience & technologyPhysical sciencesChemistry, physicalChemistryArticle00052070370000425662571150910.1007/s10562-020-03175-21572-879X