Yılmaz, YusufYonal, OyaKurt, RamazanAlahdab, Yeşim ÖzenÖzdogan, OsmanÇelikel, Çiğdem Ataiziİmeryuz, NeşeKalaycı, CemAvşar, Erol2021-12-292021-12-292011-01Yılmaz, Y. vd. (2011). ''Circulating levels of vascular endothelial growth factor A and its soluble receptor in patients with biopsy-proven nonalcoholic fatty liver disease''. Archives of Medical Research, 42(1), 38-43.0188-4409https://doi.org/10.1016/j.arcmed.2010.12.001https://www.sciencedirect.com/science/article/pii/S0188440910003486http://hdl.handle.net/11452/23728Background and Aims. Vascular endothelial growth factor A (VEGF) is a multifunctional cytokine affecting angiogenesis and vascular function. The biological activity of VEGF is modulated by its soluble receptor VEGFR-1 (sVEGFR-1). We explored the associations of VEGF and sVEGFR-1 concentrations with liver histology in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD). Methods. The study was comprised of 99 patients with NAFLD and 75 healthy controls. Serum VEGF and sVEGFR-1 concentrations were measured using commercially available enzyme-linked immunosorbent assays. Results. Serum VEGF levels did not differ in patients with NAFLD (1882 +/- 942 pg/mL) compared with healthy controls (1985 +/- 945 pg/mL, p = 0.42). However, compared with healthy subjects, levels of sVEGFR-1 were significantly lower in patients with NAFLD (1.59 +/- 0.58 ng/mL vs. 1.16 +/- 0.34 ng/mL, respectively, p < 0.001). After allowance for potential confounders, serum sVEGFR-1 levels retained their independent significance as a predictor of liver fibrosis in patients with NAFLD (beta = -0.19; t = -1.81, p < 0.05). Conclusions. Our results show that patients with biopsy-proven NAFLD have a significant reduction in serum sVEGFR-1 concentrations that predict the degree of liver fibrosis, independent of potential confounders.eninfo:eu-repo/semantics/closedAccessResearch & experimental medicineVascular endothelial growth factorNonalcoholic fatty liver diseaseLiver fibrosisEnzyme-linked immunosorbent assaySteatohepatitisMetabolic syndromePlasma levelsVEGFAngiogenesisAssociationSteatohepatitisHypertensionSFLT-1CellsRiskAdultBiopsyFatty liverFemaleHumansLiverMaleMiddle agedVascular endothelial growth factor aVascular endothelial growth factor receptor-1Article0002885899000072-s2.0-79952084700384342121376261Medicine, research & experimentalFatty Liver; Proton Density (Concentration); Keratin-18Vasculotropin AVasculotropin receptor 1AdultArticleControlled studyEnzyme linked immunosorbent assayFemaleHumanHuman tissueLiver biopsyLiver fibrosisLiver histologyMajor clinical studyMaleNonalcoholic fatty liverProtein blood level