2022-01-182022-01-181998Egeli, Ü. (1998). "Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures". Teratogenesis Carcinogenesis and Mutagenesis, 18(4), 163-169.0270-3211https://doi.org/10.1002/(SICI)1520-6866(1998)18:4<163::AID-TCM2>3.0.CO;2-Lhttps://onlinelibrary.wiley.com/doi/10.1002/(SICI)1520-6866(1998)18:4%3C163::AID-TCM2%3E3.0.CO;2-Lhttp://hdl.handle.net/11452/24137This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes.eninfo:eu-repo/semantics/closedAccessOncologyGenetics & heredityToxicologyPyrimethamineSister chromatid exchangesHuman lymphocyte cultureGenotoxicityToxoplasmosisFragile sitesSuspected aneugensSHL cellsCancerRearrangementsInvitroAberrationsAneuploidyGeneAdultAntiprotozoal agentsCells, culturedDose-response relationship, drugFemaleHumansLymphocytesMalePyrimethamineSister chromatid exchangeArticle0000765848000022-s2.0-00317683951631691849804272OncologyGenetics & heredityToxicologyHyperpigmentation; Vitamin B 12 Deficiency; Megaloblastic AnemiaFolic acid antagonistPyrimethamineArticleCarcinogenicityCytogeneticsDna replicationDrug effectEnzyme inhibitionGenotoxicityHumanHuman cellLymphocyte cultureMutagenicityPeripheral lymphocytePriority journalProtein inductionSister chromatid exchangeToxoplasmosis