2024-04-042024-04-042008-07-15Biçer, M. vd. (2008). "Assessment of the efficacy of bio-absorbable oxidized regenerated cellulose for prevention of post-operative pericardial adhesion in the rabbit model". Journal of International Medical Research, 36(6), 1311-1318.0300-0605https://journals.sagepub.com/doi/abs/10.1177/147323000803600619https://hdl.handle.net/11452/40974Pericardial adhesions complicate re-operative cardiac surgery and several attempts have been made to reduce adhesion formation. The efficacy of bio-absorbable oxidized regenerated cellulose in preventing post-operative pericardial adhesions was evaluated in the present study. Forty New Zealand white rabbits were divided into four groups of 10. In all rabbits an area of pericardium (2 x 2 cm) was excised. The wound was left open in groups I and 2 but replaced with bio-absorbable oxidized regenerated cellulose in groups 3 and 4. Rabbits in groups 1 and 3 were killed 3 weeks after surgery and those in groups 2 and 4 were killed at 6 weeks. Groups 1 and 2 showed more severe pericardial adhesions, more fibrous reaction and increased visibility of coronary vessels than groups 3 and 4, although there was no difference in inflammation. Light microscopy showed a mesothelium-like cell layer in groups 3 and 4. It is concluded that bio-absorbable oxidized regenerated cellulose may be suitable in patients receiving staged cardiac surgery and in those with a high probability of re-operation.veninfo:eu-repo/semantics/openAccessAnimal modelBio-absorbable membraneOxidized regenerated cellulosePericardial adhesionRabbitResearch & experimental medicinPharmacology & pharmacySurgical membraneReoperationSubstituteReductionInterceedClosureAbsorbable implantsAnimalsCoronary vesselsCelluloseCellulose, oxidizedDisease models, animalFibrosisHemostaticsPericardiumPostoperative complicationsRabbitsTissue adhesionsWound healingArticle0002620247000192-s2.0-596491119271311131836619094441https://doi.org/10.1177/147323000803600619Medicine, research & experimentalPharmacology & pharmacyHeterotopic Ossification; Tenotomy; Case ReportOxidized regenerated celluloseCelluloseDrug derivativeHemostatic agentOxidized celluloseAnimal experimentAnimal modelAnimal tissueArticleControlled studyCoronary blood vesselDrug efficacyHeart surgeryInflammationNonhumanPericardial diseasePericardium adhesionPostoperative periodPrimary preventionRabbitReoperationAnimalBiodegradable implantDisease modelFibrosisPathologyPericardiumPostoperative complicationTissue adhesionWound healing1473-2300