2022-01-032022-01-032011-03Taş, S. vd. (2011). "Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats". Cell Biochemistry and Function, 29(2), 108-113.0263-6484https://doi.org/10.1002/cbf.1729https://pubmed.ncbi.nlm.nih.gov/21370246/http://hdl.handle.net/11452/23804This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus.eninfo:eu-repo/semantics/closedAccessBiochemistry & molecular biologyCell biologyUlva rigidaDiabetesOxidative stressAntioxidant statusHyperlipidemiaSerum paraoxonase activityVanadyl sulfateMellitusAntioxidantExtractMiceAtherosclerosisAminoguanidineHyperglycemiaComplicationsChlorophytaRattusRattus norvegicusUlva rigidaAnimalsBlood glucoseCarbohydrate metabolismDiabetes mellitus, experimentalDisease models, animalHumansHyperlipidemiasMaleMalondialdehydeOxidative stressPlant preparationsRandom allocationRatsRats, wistarUlvaArticle0002880794000052-s2.0-7995221719210811329221370246Biochemistry & molecular biologyCell BiologyAryldialkylphosphatase; Arylesterase; Human PON1 ProteinAlgal extractAntidiabetic agentAryldialkylphosphataseArylesteraseDrinking waterGlutathione peroxidaseInsulinMalonaldehydeSuperoxide dismutaseUlva rigida extractUnclassified drugAlgaAnimal experimentArticleBloodCarbohydrate metabolismCholesterol blood levelDiabetes mellitusDrug effectEnzyme activityErythrocyteGlucose blood levelHyperlipidemiaInsulin blood levelMaleNonhumanOxidative stressPriority journalRatStreptozocin diabetesTissue levelTriacylglycerol blood levelUlva rigida