2022-09-132022-09-132007-04Şentürk, T. vd. (2007). "Procalcitonin in patients with acute coronary syndrome: Correlation with high-sensitive C-reactive protein, prognosis and severity of coronary artery disease". Acta Cardiologica, 62(2), 135-141.0001-53851784-973Xhttps://doi.org/10.2143/AC.62.2.2020233https://poj.peeters-leuven.be/content.php?url=article&id=2020233&journal_code=AChttp://hdl.handle.net/11452/28667Objectives - The aim of this study is to determine the relation of high-sensitive serum C-reactive protein (hsCRP) and procalcitonin with presence and severity of coronary artery disease and early prognosis in patients with acute coronary syndrome (ACS). Methods and results - Procalcitonin and hsCRP levels were measured at admission and after 48 hours in 50 patients (41 men, 9 women) with ACS. The patients were assigned to three groups according to their clinical diagnosis: unstable angina pectoris (UAP) (Braunwald III-B), non-ST-segment elevation myocardial infarction (NSTEMI) and ST-segment elevation myocardial infarction (STEMI). Incidences of adverse cardiac events were recorded in a 3-month follow-up. Coronary angiography was performed to evaluate presence and severity of coronary artery disease. In the groups of STEMI, NSTEMI and UAP, procalcitonin (P = 0.013, P = 0.045 and P = 0.0001, respectively) and hsCRP (P = 0.0001, P = 0.01 and P = 0.001, respectively) levels were significantly increased. No significant correlation was found between these markers and the presence and severity of coronary artery disease. There was no correlation between procalcitonin and hsCRP levels at admission and after 48 hours and primary end points after 3 months except in the group of UAP with revascularization procedure. In the group of UAP, hsCRP levels at 48 hours were found higher in the patients with a revascularization procedure (P = 0.04). Conclusions - In conclusion, levels of hsCRP and procalcitonin are increased in patients with ACS but failed to correlate with severity of coronary disease and early prognosis.eninfo:eu-repo/semantics/closedAccessAcute coronary syndromehsCRPProcalcitoninPrognosisAcute myocardial-infarctionPractice guidelines committeeAssociation task-forceUnstable anginaCardiovascular-diseaseAcc/Aha guidelinesAmerican-collegeInflammationAtherosclerosisManagementAnalysis of varianceAcute diseaseAdultAgedC-Reactive proteinResearch designAngina, unstableAngioplasty, transluminal, percutaneous coronaryCoronary artery bypassCalcitoninCoronary angiographyCoronary arteriosclerosisFemaleCreatine kinase, MB formMaleFollow-up studiesHumansInflammation mediatorsMiddle agedMyocardial infarctionPrognosisSyndromeProtein precursorsSeverity of illness indexTreatment outcomeTroponin ITurkeyArticle0002460632000042-s2.0-3424746844513514162217536601Cardiac & cardiovascular systemsProcalcitonin; Sepsis; C Reactive ProteinCD8+ T lymphocyteC reactive proteinImmunoglobulin APlaceboProbiotic agentReflorUnclassified drugAcute diarrheaAcute gastroenteritisArticleHumanChildClinical trialControlled clinical trialControlled studyDouble blind procedureFemaleFollow upImmune responseProtein blood levelImmunoglobulin blood levelInfantLymphocyte countMaleNonhumanOral rehydration therapyRandomized controlled trialSaccharomyces boulardii