Tvarijonaviciute, A.Martinez-Subiela, S.Tecles, F.2023-10-052023-10-052015-02-01Kocaturk, M. (2015). "Inflammatory and oxidative biomarkers of disease severity in dogs with parvoviral enteritis". Journal of Small Animal Practice, 56(2), 119-124.0022-45101748-5827https://doi.org/10.1111/jsap.12250https://onlinelibrary.wiley.com/doi/10.1111/jsap.12250http://hdl.handle.net/11452/34222Objectives: To study changes in serum C-reactive protein, haptoglobin, ceruloplasmin and albumin concentration, total anti-oxidant capacity and paraoxonase-1 and butyrylcholinesterase activity in dogs with parvoviral enteritis of different degrees of clinical severity.Methods: Prospective study of 9 healthy and 43 dogs with parvoviral enteritis that were classified into mildly, moderately and affected groups.Results: Dogs with parvoviral enteritis had a significant increase in C-reactive protein compared with healthy dogs, with an increase of higher magnitude in animals with more severe clinical signs. All dogs with parvoviral enteritis had a significant increase in haptoglobin concentration compared with healthy dogs, but with no difference according to disease severity. There was a decrease in paraoxonase-1 activity in parvoviral enteritis.Clinical significance: Major increases of C-reactive protein concentrations in dogs with parvoviral enteritis are a marker of disease severity. In addition, higher values for anti-oxidants in severe cases compared with mild and moderate cases suggest a possible compensatory anti-oxidant mechanism.eninfo:eu-repo/semantics/closedAccessAcute-phase proteinsC-reactive proteinAntioxidant capacityCanine parvovirusParaoxonase activitySerumPlasmaButyrylcholinesteraseHaptoglobinValidationAnimaliaCanis familiarisVeterinary sciencesAnimalsBiomarkersC-reactive proteinCase-control studiesCeruloplasminDog diseasesDogsEnteritisFemaleHaptoglobinsInflammationMaleOxidation-reductionParvoviridae infectionsProspective studiesSerum albuminSeverity of illness indexAryldialkylphosphataseArticle0003490248000072-s2.0-8492265779111912456225040669Veterinary sciencesCanine parvovirus; Feline panleukopenia virus; DogAryldialkylphosphataseBiological markerC reactive proteinCeruloplasminHaptoglobinSerum albuminAnimalBloodCase control studyDogDog diseasesEnteritisFemaleInflammationMaleOxidation reduction reactionParvoviridae infectionsProspective studySeverity of illness indexVeterinary