Aksoy, Meliha KasapoğluAltan, LaleGörükmez, OrhanGüner, AltuğAyar, Koray2024-07-232024-07-232019-07-201439-7595https://doi.org/10.1080/14397595.2019.1639916https://academic.oup.com/mr/article-abstract/30/4/715/6300352https://hdl.handle.net/11452/43374Background: We aimed to investigate the haplotypes and alleles of two variants (rs2794521 and rs3091244) in AS patients and to examine their relationship with ASDAS-CRP and ASDAS-ESR values. Methods: We evaluated 160 AS patients diagnosed according to the ASAS criteria. ASDAS-CRP and ASDAS-ESR values were calculated. ESR and CRP were examined. The restriction fragment length polymorphism (RFLP) method was used for detecting the rs2794521 and rs3091244 regions on the CRP gene. Results: As a result of the evaluation of rs2794521 gene polymorphism using PCR, TT, TC and CC genotypes were observed in 90, 81 and 9 individuals, respectively. As a result of the evaluation of rs3091244 gene polymorphism, CC, AC and TT genotypes were observed in 104, 51 and 5 individuals, respectively. T allele and C allele were found in rs2794521 gene by 75% and 25%, respectively. In addition, T allele, C allele and A allele were found in rs3091244 gene by 80%, 17% and 3%, respectively. With the help of regression equation, ASDAS-CRP level was 0.34 units higher in cases with rs3091244 C allele than cases without rs3091244 C alleles. Conclusion: CRP rs3091244 C allele may be associated with the increased relative risk for ASDAS-CRP.eninfo:eu-repo/semantics/closedAccessC-reactive proteinDisease-activityAssociationHla-b27SpondyloarthritisPredictionPromoterCancerAlleleSnpAnkylosing spondylitisCrp gene polymorphismAsdas crpAsdas esrAcute phase reactantsScience & technologyLife sciences & biomedicineRheumatologyArticle00047723950000171572030410.1080/14397595.2019.16399161439-7609