2024-10-042024-10-042022-07-080020-7454https://doi.org/10.1080/00207454.2022.2098731https://hdl.handle.net/11452/45835Introduction There is limited data about the neurological effects of Covid-19 in infected patients. In this report, we present 2 LETM cases that are possibly associated with Covid-19 infection. Methods Here, we present 2 cases that subsequently developed LETM following Covid-19 infection. The first case presented a finding of tetraparesis prominent in the lower extremities that started ten days after the Covid-19 infection. The second patient was admitted with paraparesis and urinary-stool retention on the 12th day from the onset of symptoms of Covid-19 infection. Results In these 2 cases, LETM developing following Covid'19 infection was associated with Covid-19 infection. Although Covid-19 PCR was negative in the CSF of both patients, the Covid-19 PCR test was positive in the samples taken from the oropharynx. Conclusion The mechanism of LETM caused by Covid-19 infection is not clearly known. However, both direct infection of the spinal cord and excessive inflammatory response to primary Covid-19 infection may cause spinal cord damage. Therefore, possible Covid-19-associated myelitis should be kept in mind in cases of long segment transverse myelitis grouped under the title of NMOSD and without any etiological factor.eninfo:eu-repo/semantics/closedAccessLongitudinally extensive transverse myelitisCovid-19Central nervous system manifestationsScience & technologyLife sciences & biomedicineNeurosciencesNeurosciences & neurologyArticle000824368700001193196134210.1080/00207454.2022.2098731