Sayan, MuratÖzgüler, MügeYıldırım, FigenYıldırmak, TanerGündüz, AlperDokuzoğuz, BaşakÇelen, Mustafa Kemalİnan, DilaraErsöz, GüldenKaraoğlan, İlkayCeran, Nurgül2022-12-222022-12-222020-02-24Sayan, M. vd. (2020). "Molecular identification of HIV-1 in the presence of hepatitis B virus and hepatitis C virus Co-infections". Balkan Medical Journal, 37(3), 125-130.2146-31232146-3131https://doi.org/10.4274/balkanmedj.galenos.2020.2019.5.89https://www.balkanmedicaljournal.org/uploads/pdf/pdf_BMJ_2188.pdfhttp://hdl.handle.net/11452/30023Bu çalışma, 14-17 Eylül 2016 tarihleri arasında Lizbon[Portekiz]'de düzenlenen 19. Meeting of the European Society for Clinical Virology'de bildiri olarak sunulmuştur.Background: Because of their similar modes of transmission, the simultaneous infection of viral hepatitis and human immunodeficiency virus are increasingly seen as a big problem related to human health. Aims: To determine the drug mutations in hepatitis B virus and/or hepatitis C virus co-infected human immunodeficiency virus-1 patients in Turkey. Study Design: Retrospective cross-sectional study. Methods: The present study was conducted between 2010 and 2017. HBsAg, anti-hepatitis C virus, and anti-human immunodeficiency vim were tested with ELISA. All anti-human immunodeficiency virus positive results by ELISA were verified for anti-human immunodeficiency virus positivity by a Western blot test, and Antihuman immunodeficiency virus positive patients with HBsAg andior anti-hepatitis C virus positivity were included in the study. Subtyping and genotypic resistance analyses were performed by population sequencing of the viral protease and reverse transcriptase regions of the human immunodeficiency virus-1 pol gene. Results: We detected 3896 human immunodeficiency virus-1 positive patients whose sera were sent from numerous hospitals across the country to our polymerase chain reaction unit for detection of drug resistance mutations and whose molecular laboratory tests were completed. Viral hepatitis co-infections were detected in 4.3% (n=170) of patients. Hepatitis B virus and hepatitis C virus co-infection were observed in 3.2% and 0.5% of all human immunodeficiency virus-I infected patients, respectively. The major human immunodeficiency virus-1 subtype detected was group M, subtype B (62.9%). However, 13.5% of drug resistance mutation motifs were found in human immunodeficiency virus-1 genomes of patients included in the study. Conclusion: Due to similar transmission routes, HIV1 patients are at risk of hepatitis B and C virus co-infection. However, antiretroviral drug resistance mutation model is similar to patients with hepatitis negative.eninfo:eu-repo/semantics/openAccessCo-infectionHepatitis B virusHepatitis C virusHIV-1Molecular epidemiologyInfectionsAdultsImpactGeneral & internal medicineCoinfectionCross-sectional studiesHepacivirusHepatitis BHepatitis B virusHepatitis CHIV infectionsHumansPolymerase chain reactionRetrospective studiesTurkeyArticle0005260821000032-s2.0-8508362146312513037332106666Medicine, general & internalViral Load; Dried Blood Spot Testing; Human Immunodeficiency Virus 1Hepatitis B surface antigenNonnucleoside reverse transcriptase inhibitorProteinaseProteinase inhibitorRNA directed DNA polymeraseRNA directed DNA polymerase inhibitorAdultArticleControlled studyCross-sectional studyDisease transmissionEnzyme linked immunosorbent assayFemaleGene mutationGene sequenceGenotypeHepatitis BHepatitis CHumanHuman immunodeficiency virus infectionInfection riskLaboratory testMajor clinical studyMaleMixed infectionMolecular epidemiologyPolymerase chain reactionPrevalenceEtrospective studyTurkey (republic)Virus detectionVirus geneVirus resistanceWestern blottingHepacivirusHepatitis BHepatitis B virusHepatitis CHuman immunodeficiency virus infectionMixed infectionPathogenicityPathophysiologyProceduresTurkey (bird)Virology