2022-04-272022-04-272004İlçöl, Y. Ö. vd. (2004). “Declines in serum free and bound choline concentrations in humans after three different types of major surgery”. Clinical Chemistry and Laboratory Medicine, 42(12), 1390-1395.1434-6621https://doi.org/10.1515/CCLM.2004.259https://www.degruyter.com/document/doi/10.1515/CCLM.2004.259/htmlhttp://hdl.handle.net/11452/26131We examined the changes in circulating choline status in humans in response to major surgery by measuring serum free and phospholipid-bound choline concentrations before, during and 1-72 h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery. Preoperatively, the mean serum free and phospholipid-bound choline concentrations in patients scheduled for abdominal hysterectomy (n=26), off-pump coronary artery grafting surgery (n=34) or brain tumor surgery (n=24) were 12.3+/-0.5, 12.1+/-0.4 and 11.4+/-0.4 mumol/l, and 2495+/-75, 2590+/-115 and 2625+/-80 mumol/l, respectively. Serum free choline and phospholipid-bound choline concentrations decreased from these baseline values to 8.8+/-0.7 (p<0.001), 8.8 +/- 0.5 (p<0.001) and 8.2+/-0.4 mumol/l (p<0.001), and 2050 +/- 108 (p<0.001), 2166+/-59 (p<0.001) and 1884 +/- 104 mu mol/l (p<0.001) at 1 h after hysterectomy, off-pump bypass graft surgery or brain tumor surgery, respectively. They remained at these low levels for 24 h and then gradually increased towards the preoperative values at 48-72 h postoperatively. Serum cortisol increased postoperatively in all surgical patients for 24 h and its levels were inversely correlated with serum free and bound choline concentrations. These results show that circulating free and bound choline concentrations decrease for 72 h after total abdominal hysterectomy, off-pump coronary artery graft surgery or brain tumor surgery in humans.eninfo:eu-repo/semantics/closedAccessMedical laboratory technologyBound cholineBrain surgeryCortisolFree cholineHysterectomySurgical stressTyrosine-hydroxylaseAcetylcholine-releaseEssential nutrientPlasma cholineRatBrainMechanismsIncreasesDecreaseInductionAdultAgedBrain neoplasmsCholineCoronary artery bypassFemaleHumansHydrocortisoneHysterectomyMaleMiddle agedNeurosurgical proceduresPhospholipidsTime factorsUterine neoplasmsArticle0002259066000072-s2.0-1124430245313901395421215576301Medical laboratory technologyCholine; Dimethylglycine; PregnancyAbdominal hysterectomyAdultAgedArticleBlood levelBrain surgeryBrain tumorCirculationControlled studyCorrelation functionFemaleHumanMajor clinical studyMajor surgeryMaleOff pump coronary surgeryPostoperative periodPreoperative periodPriority journalStatistical analysisSurgical patientCholinePhospholipid