2022-04-252022-04-252010-03Ersoy, C. vd. (2010). "Body fat distribution has no effect on serum visfatin levels in healthy female subjects". Cytokine, 49(3), 275-278.1043-4666https://doi.org/10.1016/j.cyto.2009.11.011https://www.sciencedirect.com/science/article/pii/S1043466609008722http://hdl.handle.net/11452/26058Obesity is the presence of either abnormal absolute amount or relative proportion of body fat. Contrary to gluteal obesity, visceral obesity is associated with different metabolic alterations including insulin resistance (IR). A relatively new adipocytokine visfatin is shown to be expressed predominantly in visceral fat and exhibit insulin-mimicking effects in rodents. It is still unclear whether serum visfatin levels are associated with increased total or visceral fat mass in humans. The aim of our study was to investigate the relation between visfatin and obesity parameters namely body mass index (BMI) and waist circumference (WaC) and IR in healthy female subjects. Eighty one female subjects >= 20 years of age, having no diagnosis of glucose intolerance or diabetes, hypertension and dyslipidemia were chosen. The patients were divided into four groups according to their BMI and WaC values. Serum visfatin and HOMA-IR levels did not differ among groups. No correlation was detected between serum visfatin levels and obesity and metabolic parameters. In conclusion, we demonstrated that body fat distribution did not affect serum visfatin levels in healthy female subjects. Further studies are needed to clarify the exact factors influencing and determining serum visfatin levels and its clinical reflections.eninfo:eu-repo/semantics/closedAccessGeneral obesityVisceral obesityVisfatinType-2-diabetes-mellitusColony-enhancing factorInsulin-resistanceViscelar fatMetabolic syndromePlasmaCholesterolOverweightGlucoseProteinBiochemistry & molecular biologyCell biologyImmunologyRodentiaAdultBlood glucoseBody fat distributionBody mass indexCross-sectional studiesFemaleHumansInsulinInsulin resistanceIntra-abdominal fatMiddle agedNicotinamide phosphoribosyltransferaseObesityProspective studiesWaist circumferenceArticle0002753534000072-s2.0-7544908549027527849320045351Biochemistry & molecular biologyCell biologyImmunologyNicotinamide Phosphoribosyltransferase; Nicotinamide-Beta-Riboside; NiacinamideNicotinamide phosphoribosyltransferaseAdultArticleBody fat distributionBody massControlled studyCorrelational studyEnzyme blood levelFemaleHumanHuman experimentInsulin resistanceMetabolic parametersNormal humanObesityPatient assessmentPatient identificationPriority journalWaist circumference