2024-03-192024-03-192008Çetinkaya, M. vd. (2008). "Hyperprostaglandin E syndrome: Use of indomethacin and steroid, and death due to necrotizing enterocolitis and sepsis". Turkish Journal of Pediatrics, 50(4), 386-390.0041-4301https://hdl.handle.net/11452/40474Hyperprostaglandin E syndrome (HPS) is the antenatal variant of Bartter syndrome and characterized by polyhydramnios and preterm delivery in the antenatal period and salt-wasting, isosthenuric or hyposthenuric polyuria, hypercalciuria and nephrocalcinosis in the postnatal period. We report a one-month-old infant with HPS with a 15-year-old sister with Bartter syndrome. The infant's birth weight was 2750 g and she had severe dehydration on the 2nd day of life. She had hypercalcemia, hyponatremia, hypokalemia, metabolic alkalosis and elevated plasma renin and aldosterone levels. We instituted indomethacin therapy accompanied by steroid therapy for hypercalcermia. However, the patient developed abdominal distention on the 30th day, which was due to diffuse pneumatosis in sigmoid colon revealed by a subsequent surgical intervention. Following surgery, the patient developed fever, electrolyte abnormalities and subsequently sepsis. The patient died due to sepsis 10 days after surgery. We conclude that indomethacin and steroid therapy must be used cautiously in infants with HPS.eninfo:eu-repo/semantics/closedAccessAntenatal Bartter syndromeDeathHyperprostaglandin E syndromeIndomethacinNecrotizing enterocolitisSteroidBirth-weight infantsBartter-syndromeHypercalciuriaTherapyVariantManagementPediatricsAnti-inflammatory agents, non-steroidalBartter syndromeEnterocolitis, necrotizingFatal outcomeFemaleHumansIndomethacinInfant, newbornPolyhydramnioPregnancySepsisSteroidsArticle0002605130000162-s2.0-5814918398138639050419014056PediatricsGitelman Syndrome; Loop of Henle; MutationAldosteroneAamikacinCalciumClindamycinFluconazoleFurosemideImmunoglobulinIndometacinMeropenemPotassiumProstaglandin EReninSodiumSodium chlorideSteroidNonsteroid antiinflammatory agentSteroidAbdominal distensionArticleBartter syndromeBirth weightCase reportColon surgeryColostomyDeathDehydrationDisease severityDrug dose increaseElectrolyte disturbanceFamily historyFemaleFeverFluid therapyHumanHydramniosHypercalcemiaHypercalciuriaHypokalemiaHyponatremiaInfantKidney calcificationMetabolic alkalosisPerinatal periodPneumatosis intestinalisPolyuriaPostoperative periodPremature laborPrenatal periodSalt wastingSepsisThrombocytopeniaBartter syndromeFatalityNecrotizing enterocolitisNewbornPathophysiologyPregnancyIndometacin