Vural, Ahmet HakanKoçoğulları, Cevdet UǧurÖzcan, AyhanYalçınkaya, SerhatBayer, AhmetÖzyazıcıoğlu, Ahmet FatihGöncü, Tuğrul2024-03-202024-03-202008-10Vural, A.H. vd. (2008). "Histological results of sclerotherapy, phototherapy, and pulsed 980-nm laser irradiation of the dorsal rabbit ear vein". Photomedicine and Laser Surgery, 26(5), 467-471.https://www.liebertpub.com/doi/10.1089/pho.2007.22241549-5418https://doi.org/10.1089/pho.2007.2224https://hdl.handle.net/11452/40509Objective: To compare the histological changes occurring after three different treatment modalities for telangiectasias. Materials and Methods: Thirty 16-week-old New Zealand white rabbits weighing 2.4-3.1 kg were enrolled in the study. The rabbits were divided into three groups. The group 1 received sclerotherapy, he group 2 received phototherapy, and group 3 received high-power diode laser treatments. All animals were treated on the right dorsal marginal ear vein. Biopsies were taken on days 1, 2, 7, and 30 post-treatment, and histopathogical evaluation was performed. Results: Clinical and histological thrombosis occurred between days 1 and 7 in all groups. Superficial necrosis, neutrophil infiltration, and recanalization were mostly seen in group 3, whereas thrombosis was prominent in groups 1 and 2. Conclusions: All of the methods tested appear to have similar mechanisms of action, but had differing clinical and histological results. Phototherapy and laser treatment are non-invasive and do not require an exact, pinpoint technique, in contrast to sclerotherapy. However, sclerotherapy and phototherapy showed better results, especially with regard to recanalization.eninfo:eu-repo/semantics/closedAccessHeliumLasersHigh-powerHistological changesLaser irradiationsLaser treatmentsNeutrophil infiltrationsNew zealand white rabbitsPhototherapyRecanalizationSclerotherapyTreatment modalitiesPulsed laser applicationsNd-yag laserNm diode-laserLeg veinsDye-laserVascular-lesionsTelangiectasiaSurgeryAnimalsEar, externalLaser therapyPhototherapyRabbitsSclerotherapyTelangiectasisVeinsArticle0002605036000102-s2.0-5404915783046747126518800948SurgeryPort-Wine Stain; Low Level Laser Therapy; Hematoporphyrin Monomethyl EtherAnimal experimentAnimal tissueArticleDiode laserEarHistologyHistopathologyIntermethod comparisonNecrosisNeutrophil chemotaxisNonhumanPhototherapyRecanalizationRabbitSclerotherapyTelangiectasiaThrombosis