Özdemir, Gül N.Ayçiçek, Ali2024-11-052024-11-052023-04-011077-4114https://doi.org/10.1097/MPH.0000000000002468https://hdl.handle.net/11452/47427Splenectomy is indicated in transfusion-dependent thalassemia (TDT) only in certain situations. This study aimed to present the effectiveness, complications, and long-term follow-up results of splenectomy in children with TDT. We performed a 30-year single-institution analysis of cases of splenectomy for TDT between 1987 and 2017 and their follow-up until 2021. A total of 39 children (female/male: 24/15) were included. The mean age at splenectomy was 11.2 +/- 3.2 years, and their mean follow-up duration after splenectomy was 21.5 +/- 6.4 years. Response was defined according to the patient's annual transfusion requirement in the first year postsplenectomy and on the last follow-up year. Complete response was not seen in any of the cases; partial response was observed in 32.3% and no response in 67.6%. Thrombocytosis was seen in 87% of the patients. The platelet counts of 7 (17.9%) patients were >1000 (10(9)/L), and aspirin prophylaxis was given to 22 (56.4%) patients. Complications were thrombosis in 2 (5.1%) patients, infections in 11 (28.2%) patients, and pulmonary hypertension in 4 (10.2%) patients. Our study showed that after splenectomy, the need for transfusion only partially decreased in a small number of TDT patients. We think splenectomy can be delayed with appropriate chelation therapy up to higher annual transfusion requirement values.eninfo:eu-repo/semantics/closedAccessLaparoscopic splenectomyMagnetic-resonanceChelation-therapyPrevalenceStrategiesSepsisSplenectomyChildrenThalassemiaTransfusion-dependentLong-termScience & technologyLife sciences & biomedicineOncologyPediatricsHematologyArticle00095794310000714314845310.1097/MPH.0000000000002468