Ayyıldız, Talat2022-08-182022-08-182014Ayyıldız, T. vd. (2014). "Association of adiponectin receptor (Adipo-R1/-R2) expression and colorectal cancer". Asian Pacific Journal of Cancer Prevention, 15(21), 9385-9390.1513-7368https://doi.org/10.7314/APJCP.2014.15.21.9385http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:25422229&key=2014.15.21.9385http://hdl.handle.net/11452/28260Introduction: Human adiponectin (ApN) is a 30 kDa glycoprotein of 244-amino acids which is extensively produced by adipocytes. ApN acts via two receptors, namely adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Studies have shown the presence of Adipo-R1 and Adipo-R2 expression immunohistochemically in human colorectal cancers (CRCs). However, only a few studies exist which investigated effects of adiponectin receptor expression on CRC characteristics. Objectives: In the present study, we aimed to explore Adipo-R1/-R2 expression in human colorectal cancers and any association with clinicopathological characteristics and survival. Materials and Methods: The study enrolled 58 colorectal cancer patients with tumor resection and a control group of 30 subjects with normal colon mucosa. Results: Positivity for Adipo-R1/-R2 expression was significantly more common in the control group in comparison to the patient group (both p<0.001). There was no significant association between Adipo-R1/-R2 expression and clinicopathological characteristics including age, sex tumor location, pTNM stage, Duke's stage, metastasis, histological differentiation, perineural invasion, venous invasion sex, lymphatic invasion, cancer-related mortality, tumor size and recurrence. AdipoR1/-R2 positivity was also not significantly linked to progression-free or overall survival [p values (0.871, 0.758) and (0.274, 0.232), respectively]. Conclusions: Although significantly reduced Adipo-R1/-R2 expression was found in colorectal cancer patients, it had no influence on survival.eninfo:eu-repo/semantics/openAccessAdiponectin receptorAdipo-R1/-R2Colorectal carcinomaPrognosisPlasma adiponectinColon-cancerSerum adiponectinInsulin sensitivityTissue expressionGastric-cancerRiskProteinObesityHypoadiponectinemiaOncologyAdenocarcinomaAgedBiopsy, needleCase-control studiesColorectal neoplasmsDatabases, factualDisease-free survivalFemaleFollow-up studiesGene expression regulation, neoplasticHumansImmunohistochemistryIncidenceMaleMiddle agedReceptors, adiponectinReference valuesRetrospective studiesRisk assessmentSurvival analysisTime factorsArticle0003510561000522-s2.0-8491850963293859390152125422229OncologyLeptin Receptors; Adiponectin; ObesityAdiponectin receptorAdenocarcinomaAgedCase control studyColorectal tumorDisease free survivalFactual databaseFemaleFollow upGene expression regulationGeneticsHumanImmunohistochemistryIncidenceMaleMiddle agedMortalityNeedle biopsyPathologyReference valueRetrospective studyRisk assessmentSurvivalTime