2022-04-282022-04-282003-03-27İlçöl, Y. Ö. vd. (2003). “Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs”. Neuroscience Letters, 339(3), 195-198.0304-3940https://doi.org/10.1016/S0304-3940(03)00035-1https://www.sciencedirect.com/science/article/pii/S0304394003000351http://hdl.handle.net/11452/26237We designed this study to determine whether serum free and phospholipid-bound choline concentrations change after surgery or methylprednisolone treatment in dogs and rats. In dogs, serum free and phospholipid-bound choline concentrations were decreased by 29% and 17% immediately after abdominal-pelvic surgery under xylasine + ketamine anesthesia, respectively, and both remained low for 24 h. Serum cortisol was elevated after surgery. The elevation in serum cortisol was inversely correlated with the decreases in free (r = -0.737; P < 0.001) and phospholipid-bound (r = -0.771; P < 0.001) choline concentrations. After methyprednisolone administration (5-20 mg/kg) free and phospholipid-bound choline concentrations decreased in a dose- and time-dependent manner. In rats, either surgery or methylprednisolone failed to alter serum free choline concentrations while phospholipid-bound choline decreased after surgery. These data show that the decrease in serum choline after surgery results from the increase in circulating glucocorticoids.eninfo:eu-repo/semantics/closedAccessNeurosciences and neurologyFree cholinePhospholipid-bound cholineStressGlucocorticoidDogMethylprednisoloneCortisolAcetylcholineStressArticle0001816416000062-s2.0-0037468578195198339312633886NeurosciencesCholine; Dimethylglycine; PregnancyAbdominal surgeryAnesthesiaArticleBlood analysisControlled studyDogDose time effect relationDrug effectFemaleHydrocortisone blood levelNonhumanPelvis surgeryPriority journalRatCholineHydrocortisoneKetamineMethylprednisolonePhospholipidXylazine