2023-06-162023-06-162014-10Biçer, M. vd. (2014). "Effects of off-pump versus on-pump coronary artery bypass grafting: Apoptosis, inflammation, and oxidative stress". Heart Surgery Forum, 17(5), E271-E276.1098-35111522-6662https://journal.hsforum.com/index.php/HSF/article/view/948/954https://doi.org/10.1532/HSF98.2014326http://hdl.handle.net/11452/33063Background: It has been suggested that off-pump coronary artery bypass grafting (CABG) surgery reduces myocardial ischemia-reperfusion injury, postoperative systemic inflammatory response, and oxidative stress. The aim of this study was to measure serum malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), M30, and M65 levels and to investigate the relationship between M30 levels and oxidative stress and inflammation in patients undergoing on-and off-pump CABG surgery. Methods: Fifty patients were randomly assigned to on-pump or off-pump CABG surgery (25 patients off-pump and 25 on-pump CABG surgery), and blood samples were collected prior to surgery, and 30 minutes, 60 minutes, 6 hours, and 24 hours after CABG surgery. Results: Compared to the on-pump group, serum MDA levels at 30 minutes, 60 minutes, 6 hours, and 24 hours after the CABG surgery were significantly lower in the off-pump group (P = .001, P = .001, P = .001, and P = .001, respectively). Serum M30 levels were found to be elevated in both groups, returning to baseline at 24 hours. When compared to baseline, the hs-CRP level reached its peak at 24 hours at 13.28 +/- 5.32 mg/dL in the on-pump group, and 15.44 +/- 4.02 mg/dL in the off-pump group. Conclusion: CABG surgery is associated with an increase in inflammatory markers and serum M30 levels, indicating epithelial/endothelial apoptosis in the early period.eninfo:eu-repo/semantics/closedAccessEndothelial apoptosisPlasmaCell apoptosisCytokeratin-18OperationsSerumCardiovascular system & cardiologySurgeryAdultApoptosisCoronary artery bypassCoronary artery diseaseFemaleHumansInflammationMaleMiddle agedOxidative stressReactive oxygen speciesTreatment outcomeArticle0003479149000102-s2.0-84928806218E271E27617525367242Cardiac & cardiovascular systemsSurgeryOff Pump Coronary Surgery; Coronary Artery Bypass Graft; Bypass SurgeryAdultAntibody blood levelApoptosisArticleBlood samplingCoronary artery bypass graftCoronary artery surgeryEndothelium cellEpithelium cellFemaleHumanInflammationMajor clinical studyMaleMediastinitisMiddle agedMortalityNeurological complicationOff pump coronary surgeryOn pump coronary surgeryOxidative stressPriority journalProtein blood levelApoptosisControlled studyCoronary artery bypass graftCoronary artery diseaseImmunologyInflammationOxidative stressProceduresRandomized controlled trialTreatment outcomeBiological markerC reactive proteinMalonaldehydeMonoclonal antibodyMonoclonal antibody m30Monoclonal antibody m65Unclassified drugReactive oxygen metabolite