Benan, MüsellimNesrin, MoğulkoçOğuz, UzunFatma, Tokgöz AkyılHaluk, TürktaşÖzlem, Özdemir KumbasarGülfer, OkumuşCandan, OğusHülya, DirolAdil, ZamaniTülin, SevimNihat, Annakkaya AliAkıncı, Özyurek Bernaİsmail, HantaYusuf, AydemirEbru, Çakır EdisBahar, KurtCan, Tertemiz KemalLevent, TabakOnur, YazıcıYurdanur, ErdoğanGüngör, AteşHatice, TürkerBanu, SalepciArmağan, HazarYelda, Niksarlioğlu ElifBilge, Yılmaz KaraNurdan, KöktürkFüsun, KalpaklıoğluIşıl, UzelSavaş, ÖzsuErsan, AtahanZeynep, Fendoğlu TürkanSüreyya, YılmazIlknur, BaşyiğitGüngör, CamsarıEsin, TuncayElif, Uçar YilmazelDilek, KanmazAydanur, EkiciFüsun, TopcuEsra, UzaslanFulsen, BozkuşSerap, Argun BarışSerap, DuruGöksel, AltınışıkZüleyha, BingölAtadan, TunacıRecep, SavaşFatih, AlperSelen, BayraktaroğluTuba, Selçuk CanArslan, Demir Ali2024-06-072024-06-072021-03-01https://doi.org/10.5152/TurkThoracJ.2021.20028https://thoracrespract.org/en/evaluation-of-patients-with-fibrotic-interstitial-lung-disease-preliminary-results-from-the-turk-uip-study-131756https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051299/https://hdl.handle.net/11452/41865OBJECTIVE: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF.MATERIAL AND METHODS: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERSARS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board.RESULTS: A total of 336 patients (253 men, 83 women, age 65.8 +/- 9.0 years) were evaluated. Of the patients with sufficient data for diag-nosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPE None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPE Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively).CONCLUSION: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and EANA positivity reduce the likelihood of IPF.eninfo:eu-repo/semantics/openAccessIdiopathic pulmonary-fibrosisClinical-practiceDiagnosisEpidemiologyFibrotic interstitial lung diseasesIdiopathic pulmonary fibrosisUsual interstitial pneumoniaRespiratory systemArticle00065904070000110210922210.5152/TurkThoracJ.2021.200282149-2530