Karesioğlu, E.Çıkrıklar, H. I.Durak, V. A.Aydın, B.Ardıç, A.Armağan, E.2024-11-262024-11-262022-01-011128-3602https://hdl.handle.net/11452/48500OBJECTIVE: Mild traumatic brain injury (mTBI) cases with a normal CT scanning account for the vast majority of all TBI patients. The aim of this study was to investigate the course of serum Phosphorylated Neurofilament Heavy Chain (pNF-H) levels in the first six hours after trauma in rats in experimental mTBI.MATERIALS AND METHODS: In this experi-mental animal study, 32 female Sprague-Dawley rats were enrolled equally (n=8) into 3 experimen-tal groups and 1 control group. In experimental groups, animals were exposed to a mTBI with a free fall of 50-gram metal disc from a height of 80 cm. We compared serum pNF-H levels at the 2nd, 4th, and 6th hours after traumatic brain injury in the experimental groups with the control group.RESULTS: Serum pNF-H levels at the 2nd and 4th hours after traumatic brain injury were sta-tistically significantly higher than the control group. Serum pNF-H levels gradually decreased at the 4th and 6th hours compared to the 2nd hour and decreased to a similar level to the control group at the 6th hour after injury.CONCLUSIONS: A high serum pNF-H value, could be used in the diagnosis and management of mTBI patients.eninfo:eu-repo/semantics/closedAccessEmergency-departmentNf-hBiomarkerPathophysiologyNeurofilamentsManagementSubunitEmergency departmentMild traumatic brain injuryPhosphorylated neurofilament heavy chainScience & technologyLife sciences & biomedicinePharmacology & pharmacyArticle000877188200008692869342619