Cam, ErtuğrulYıldız, AyşegülKılıç, Ertuğrul2024-03-132024-03-132007-09Yuluǧ, B. vd. (2007). "Buprenorphine does not aggrevate ischemic neuronal injury in experimental focal cerebral ischemia". Journal of Neuropsychiatry and Clinical Neurosciences, 19(3), 331-334.0895-0172https://neuro.psychiatryonline.org/doi/epdf/10.1176/jnp.2007.19.3.331https://hdl.handle.net/11452/40361Buprenorphine has been increasingly used as maintenance therapy in opioid dependence as an alternative to methadone and other pharmacological therapies. However, available data suggest increased risk of cerebrovascular events in opioid-dependent patients. Therefore, an opioid that provides safety with regard to neurological function should be considered by opioid-dependent patients. The evidence for the in vitro neurotoxic effects of buprenorphine is rapidly increasing. In order to clarify whether buprenorphine is also neurotoxic under the condition of cerebral ischemia in vivo, we applied an acute dose of buprenorphine in a transient model of focal cerebral ischemia in rats. Our study provides preclinical evidence for the usage of buprenorphine during the postoperative period following ischemic events as well as for the maintenance therapy of opioid-dependent patients wherein the risk of cerebrovascular events is increased.eninfo:eu-repo/semantics/openAccessTraumatic injuryPsychiatrySpinal-cordNeurosciences & neurologyStrokeHeroinNaloxoneEfficacyApoptosisCellsTrialAnimalsBrain ischemiaBuprenorphineCerebral infarctionDisease models, animalDrug evaluation, preclinicalLaser-doppler flowmetryMaleNarcotic antagonistsRatsRats, wistarArticle0002491377000122-s2.0-8504769857433133419317827420https://doi.org/10.1176/appi.neuropsych.19.3.331Clinical neurologyPsychiatryNeurosciencesNabumetone; 6-Methoxy-2-Naphthylacetic Acid; Localized Surface Plasmon ResonanceBuprenorphineMethadoneBuprenorphineNarcotic antagonistAcute drug administrationAnimal experimentAnimal modelArticleBrain ischemiaControlled studyDrug indicationMaintenance therapyMaleNerve cell lesionNeurotoxicityNonhumanOpiate addictionPriority journalRatAnimalBrain infarctionBrain ischemiaDisease modelDrug screeningLaser Doppler flowmetryMethodologyPathologyWistar rat