2021-07-072021-07-071993Coşkun, N. ve Sümengen, D. (1993). ''A New Synthesis of N-Substituted-1,2,3,4-tetrahydro-4-phenylisoquinolin-3-ones''. Synthetic Communications, 23(10), 1393-1402.0039-7911https://doi.org/10.1080/00397919308011228https://www.tandfonline.com/doi/abs/10.1080/00397919308011228http://hdl.handle.net/11452/211361,2,3,4-Tetrahydro-4-phenylisoquinolin-3-ones 3 are obtained from appropriate N,N-disubstituted phenylacetamides 1, using lead tetraacetate ( LTA ) as oxidant and Lewis or proton acids as cyclizing agents. The methods for this conversion could be one stage ( method B or C ), or two stages ( method A ). The latter method was particularly developed to explain the mechanism of the reaction.eninfo:eu-repo/semantics/closedAccessChemistry4-ArylTetrahydroisoquinolinesDisubstitutedArticleA1993LB854000072-s2.0-0027158709139314022310Chemistry, organic