Tihan, Necdet DenizSak, Nazan GünerCini, Nilgün TuncelYavaş, Senem EsinDuman, UğurErsoy, SemihaKafa, İlker Mustafa2024-11-082024-11-082022-12-010717-9502https://www.scielo.cl/scielo.phphttps://hdl.handle.net/11452/47591Fifty male Wistar albino rats were divided into 5 groups; Group 1 as a sham group. Group 2 as a control group, Group 3 as 100 mg/kg CDP-choline administered group, Group as 200 mg/kg CDP-choline administered group, and Group 5 as sepsis group. The sepsis model was performed by ligating and perforating the caecum of rats. Liver and small intestine tissues were assessed either histologically or quantitatively and qualitatively. There was a significant difference between the sepsis and CDP-choline groups for liver and intestinal damage evaluated in tissue samples. (p <0.001). CDP-choline treatment partially improved dose-dependent the clinical parameters of sepsis and septic shock, reversed micro-anatomical damage caused by sepsis.eninfo:eu-repo/semantics/closedAccessSeptic shockInvolvementInjuryCdp-cholineLiverSmall intestineTissue damageScience & technologyLife sciences & biomedicineAnatomy & morphologyArticle000918579700008146614744060717-9367