2022-03-142022-03-142008-02Kırdak, T. vd. (2008). ''Does single, low-dose preoperative dexamethasone improve outcomes after colorectal surgery based on an enhanced recovery protocol? Double-blind, randomized clinical trial''. American Surgeon, 74(2), 160-1670003-1348http://hdl.handle.net/11452/24989Preoperative single, high-dose methylprednisolone administration improves postoperative outcomes after colonic surgery. Several randomized studies, including major surgeries, assessed various high-dose steroid regimens; however, evidence about the effect of administration of lower doses on postoperative outcomes in colorectal surgery is not available. The aim of the present study is to determine whether the administration of a single, low dose of dexamethasone before surgery would confer an outcome advantage after colorectal surgery. Thirty patients undergoing colorectal surgery were included in this randomized, double-blind study. Patients received 8 mg dexamethasone or serum physiologic preoperatively. Levels of Interleukin-6 and C-reactive protein, pain scores, postoperative nausea and vomiting, mobilization, complications, hospital stay, and readmissions were compared. Age, sex, indications, and operations were similar in both groups (P > 0.05). C-reactive protein and Interleukin-6 levels increased significantly postoperatively in each group (P < 0.05), but there were no differences between groups when compared (P > 0.05). There were also no significant differences between pain scores, bowel functions, mobilization, hospital stay, complication rates, and readmission rates between the two groups (P > 0.05). Preoperative 8 mg dexamethasone administration has no significant effect on reducing postoperative inflammatory response and also does not improve outcomes of colorectal. surgery.eninfo:eu-repo/semantics/closedAccessLaparoscopic cholecystectomyInflammatory responseCytokine responseSurgical stressCancerRehabilitationMuscularisMorbidityNauseaSurgeryResectionAdultAgedAged, 80 and overAnti-inflammatory agentsClinical protocolsColonDexamethasoneDouble-blind methodFemaleHumansMaleMiddle agedPreoperative careRectumTreatment outcomeArticle0002530093000162-s2.0-4094910723716016774218306871SurgeryEnhanced Recovery; Colon Resection; Colorectal SurgeryC reactive proteinDexamethasoneInterleukin 6AdultAge distributionAgedArticleClinical article;Clinical protocolClinical trialColorectal cancerColorectal surgeryControlled clinical trialControlled studyConvalescenceDose responseDouble blind procedureDrug efficacyFemaleHospital readmissionHospitalizationHumanLow drug doseMaleMobilizationPain assessmentPostoperative inflammationPostoperative nauseaPostoperative painPostoperative periodPostoperative vomitingPreoperative carePrognosisProtein blood levelRandomizationRandomized controlled trialSex difference