2023-01-232023-01-232020-03-16Pekel, G. ve Arı, F. (2020). "Therapeutic targeting of cancer metabolism with triosephosphate isomerase". Chemistry & Biodeversity, 17(5).1612-18721612-1880https://doi.org/10.1002/cbdv.202000012https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202000012http://hdl.handle.net/11452/30579The increase in glycolytic flux in cancer, known as aerobic glycolysis, is one of the most important hallmarks of cancer. Therefore, glycolytic enzymes have importance in understanding the molecular mechanism of cancer progression. Triosephosphate isomerase (TPI) is one of the key glycolytic enzymes. Furthermore, it takes a part in gluconeogenesis, pentose phosphate pathway and fatty acid biosynthesis. To date, it has been shown altered levels of TPI in various cancer types, especially in metastatic phenotype. According to other studies, TPI might be considered as a potential therapeutic target and a cancer-related biomarker in different types of cancer. However, its function in tumor formation and development has not been fully understood. Here, we reviewed the relationship between TPI and cancer for the first time.eninfo:eu-repo/semantics/closedAccessBiochemistry & molecular biologyChemistryCancerTriosephosphate isomeraseMetabolismWarburg effectCrystal-structureBreast-cancerDifferential expressionProteomic analysisEnzyme catalysisCell carcinomaIdentificationProteinsGenesGlycolysisAnimalsAntineoplastic agentsEnzyme inhibitorsHumansModels, molecularMolecular structureNeoplasmsTriose-phosphate isomeraseReview0005289354000012-s2.0-8508397046117532180338Biochemistry & molecular biologyChemistry, multidisciplinaryPyruvate Kinase Deficiency of Red Cells; Triose-Phosphate Isomerase; Hereditary Hemolytic AnemiaFatty acidGlycolytic enzymeTriosephosphate isomeraseTumor markerAntineoplastic agentEnzyme inhibitorTriosephosphate isomeraseAerobic glycolysisCarcinogenesisEnzyme inhibitionFatty acid synthesisGluconeogenesisHumanMalignant neoplasmMetabolismMetastasisNonhumanPentose phosphate cyclePhenotypeReviewAnimalChemical structureChemistryMetabolismMolecular modelNeoplasmPathology