2021-09-132021-09-131997Gürpınar, A. N. vd. (1997). "Fluconazole treatment of neonates and infants with severe fungal infections". Journal of International Medical Research, 25(4), 214-218.0300-0605https://doi.org/10.1177/030006059702500408https://journals.sagepub.com/doi/10.1177/030006059702500408http://hdl.handle.net/11452/21912A total of 24 neonates and infants, aged from 2 days to 10 months, received treatment with intravenous fluconazole for microbiologically documented or presumed fungal infection. The mean fluconazole dosage was 6 mg/kg/day (range 2 -16 mg/kg/day) and the mean duration of therapy was 25 days (range 5 - 72 days). Efficacy was evaluated in neonates with proven fungal infections, as documented by the presence of pathogen at baseline. A positive clinical response was achieved in 23 of the 24 clinically evaluable patients (96%); eradication of the fungal organism was also achieved in 23 of the 24 evaluable patients (96%). Adverse events occurred in two patients (8%) but therapy was not discontinued in either patient. The present results confirm the efficacy and safety of fluconazole in the treatment of neonates and infants with severe fungal infections.eninfo:eu-repo/semantics/closedAccessResearch & experimental medicinePharmacology & pharmacyFluconazoleAntifungal therapyCandida albicansFungal infectionNeonateInfantArticleA1997XT233000082-s2.0-00307685262142182549283996Medicine, research & experimentalPharmacology & pharmacyInvasive Candidiasis; Fluconazole; Systemic Mycosis