Yılmaz, Yusuf2022-09-072022-09-072010-01Gül, Ö. Ö. vd. (2010). "Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetes mellitus patients". Metabolism: Clinical and Experimental, 59(1), 64-69.0026-04951532-8600https://doi.org/10.1016/j.metabol.2009.07.006https://www.sciencedirect.com/science/article/pii/S0026049509002790http://hdl.handle.net/11452/28539Low levels of soluble receptor for advanced glycation end products (sRAGE) have been associated with the occurrence of vascular complications in patients with type 2 diabetes mellitus. Preliminary evidence has suggested that thiazolidinediones have the ability to modulate circulating levels of this molecule in the hyperglycemic milieu. The aim of this pilot study was to assess the differential effect of 2 different thiazolidinediones pioglitazone and rosiglitazone on plasma levels of sRAGE in type 2 diabetes mellitus patients. Sixty type 2 diabetes mellitus subjects were randomly assigned to receive pioglitazone (30 mg/d, n = 19), rosiglitazone (4 mg/d, n = 20), or placebo (medical nutrition therapy, n = 21) for 12 weeks. Changes in plasma glucose, glycosylated hemoglobin, insulin resistance (homeostasis model assessment), total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and sRAGE were evaluated at baseline and after 12 weeks. At 12 weeks, the pioglitazone (P < .001) group had a significant increase from baseline in sRAGE values that was not seen in the medical nutrition therapy and rosiglitazone groups. We conclude that, in type 2 diabetes mellitus patients, pioglitazone but not rosiglitazone significantly raised sRAGE, which may contribute to its antiatherogenic effects.eninfo:eu-repo/semantics/closedAccessSerum-levelsTherapeutic implicationsMyocardial-infarctionCardiovascular riskEndproducts srageRageDiseaseFormExpressionHypercholesterolemiaEndocrinology & metabolismBlood glucoseBody mass indexDiabetes mellitus, type 2FemaleGlycosylation end products, advancedHemoglobin A, glycosylatedHumansHypoglycemic agentsInsulin resistanceLipidsMaleMiddle agedPilot projectsPlacebosReceptors, immunologicSolubilityThiazolidinedionesComparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetes mellitus patientsArticle0002767615000112-s2.0-72049115492646959119709689Endocrinology & metabolismDiabetes Mellitus; 6 N Carboxymethyllysine; GlycationAdvanced glycation end product receptorGlucoseGlycosylated hemoglobinHemoglobin A1cHigh density lipoprotein cholesterolLow density lipoprotein cholesterolPioglitazoneRosiglitazoneTriacylglycerolAdultArticleAtherogenesisBody massCholesterol blood levelClinical trialControlled clinical trialControlled studyDiabetic dietDrug effectFemaleGlucose blood levelGlycemic controlHumanInsulin resistanceMajor clinical studyMaleNon insulin dependent diabetes mellitusPriority journalProtein blood levelRandomized controlled trialTriacylglycerol blood level