2021-12-152021-12-152011Köksal, Ö. vd. (2011). "Hemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy". Ulusal Travma ve Acil Cerrahi Dergisi, 17(3), 199-204.1306-696Xhttps://doi.org/10.5505/tjtes.2011.88155https://jag.journalagent.com/travma/pdfs/UTD-88155-RESEARCH_ARTICLE-KOKSAL.pdfhttp://hdl.handle.net/11452/23287In this study, the hemostatic efficacy of Celox (R) in rats under hypothermia or warfarin treatment was investigated. A total of forty-eight Sprague-Dawley female rats weighing 200-350 g were used in the study. Six experimental study groups were designed, as follows: Group 1: Normothermia + compression; Group 2: normothermia + Celox (R); Group 3: hypothermia + compression; Group 4: hypothermia + Celox (R); Group 5: normothermia + warfarin + compression; and Group 6: normothermia + warfarin + Celox (R). Celox (R) provided effective hemorrhage control in all three tested groups. There was a statistically significant difference between compression and Celox (R) implementation in all groups in terms of hemostasis (p-values for the normothermia, hypothermia and warfarin groups were p < 0.05, p < 0.01 and p < 0.01, respectively). Furthermore, the compression numbers were significantly lower in all of the groups that received Celox (R) than in those in which compression alone was applied (p-values for the normothermia, hypothermia and warfarin groups were p < 0.01, p < 0.01 and p < 0.001, respectively). Celox (R) provides effective hemorrhage control under conditions of normothermia, hypothermia and use of the oral anticoagulant agent warfarin.eninfo:eu-repo/semantics/closedAccessEmergency medicineBleeding controlCelox (R)HypothermiaWarfarinN-acetyl glucosamineLethal groin injuryLingual hemostasisSwine modelTopical hemostatsAnimal-modelHemorrhageTraumaSurvivalAgentsArticle0002921346000022-s2.0-7995980764619920417321935795Emergency medicineHemostatics; Gauze; CeloxCeloxChitosan derivativeChitosan linear polymerHemostatic agentUnclassified drugWarfarinAnimal experimentAnimal modelArticleBleedingBody temperatureCompression therapyControlled studyDark agouti ratDrug efficacyExperimental studyFemaleFemoral artery bleedingHemostasisInduced hypothermiaNonhumanRatTracheostomy