2022-05-182022-05-182004-01Saba, D. vd. (2004). “Off-pump bypass grafting in patients with significant left main coronary artery stenosis”. Heart and Vessels, 19(1), 8-12.0910-8327https://doi.org/10.1007/s00380-003-0717-9https://link.springer.com/content/pdf/10.1007/s00380-003-0717-9.pdfhttp://hdl.handle.net/11452/26508The aim of this study was to investigate and determine whether patients with significant (greater than or equal to%50) left main coronary artery stenosis could undergo coronary bypass on the beating heart and compare the results to those obtained using the conventional method. Prospectively collected data of patients with significant left main coronary artery disease who had undergone coronary bypass on the beating heart (group A, n=100) or with the conventional method (group B, n=100) were evaluated retrospectively. EuroSCORE values, preoperative and operative details, postoperative morbidity and mortality, and early results were compared. Groups were similar in terms of EuroSCORE, demographics, and preoperative variables. Number of distal anastomoses per patient was 3.1+/-0.9 in the beating heart group while it was 3.3+/-0.9 in the conventional group (P=0.09). Patients operated on with the conventional method had higher levels of peak creatine kinase-myocardial band, blood and blood product transfusions, and inotropic requirements, while mechanical ventilation times and hospital stay were longer. The incidence of postoperative atrial fibrillation, mediastinitis, and intra-aortic balloon usage were comparable between the groups. There was no neurological complication in group A whereas five major neurological complications (three transient ischemic attacks, two strokes) occurred in group B (P=0.06). Thirty-day mortality occurred in one patient in the beating heart group whereas five early deaths were observed in the conventional group (P=0.21). In significant left main coronary artery stenosis coronary bypass on the beating heart is a safe and effective alternative to the conventional method with the same or better early results. The long-term results need to be evaluated.eninfo:eu-repo/semantics/closedAccessCardiovascular system and cardiologyLeft main coronary artery stenosisBeating heartCoronary bypassCardiopulmonary bypassMultivessel diseaseBlood-transfusionRevascularizationExperienceSurvivalSurgeryHeartAnastomosis, surgicalCardiopulmonary bypassCase-control studiesCoronary artery bypassCoronary stenosisFemaleHumansIntraoperative careLogistic modelsMaleMiddle agedPostoperative carePostoperative complicationsRetrospective studiesArticle0001875043000022-s2.0-034678777581219114685748Cardiac and cardiovascular systemsPeripheral vascular diseaseOff Pump Coronary Surgery; Coronary Artery Bypass Graft; Bypass SurgeryAdultAgedAorta balloonArtery anastomosisArticleArtificial ventilationBlood transfusionClinical trialControlled clinical trialControlled studyCoronary artery obstructionDeathDemographyDisease severityDrug useFemaleHeart atrium fibrillationHeart beatHeart muscleHospitalizationHumanIncidenceIntermethod comparisonIntraoperative periodLeft coronary arteryMajor clinical studyMaleMediastinitisMorbidityNeurological complicationOff pump coronary surgeryPostoperative periodPreoperative periodPriority journalProspective studyRetrospective studySafetyScoring systemStrokeSurgical mortalityTransient ischemic attackTreatment indicationTreatment outcomeCreatine kinaseInotropic agent