Becher, Paul2022-11-022022-11-022017-06Yeşilbağ, K. vd. (2017). ''Variability and global distribution of subgenotypes of bovine viral diarrhea virus''. Viruses-Basel, 9(6).1999-4915https://doi.org/10.3390/v9060128https://www.mdpi.com/1999-4915/9/6/128http://hdl.handle.net/11452/29318Bovine viral diarrhea virus (BVDV) is a globally-distributed agent responsible for numerous clinical syndromes that lead to major economic losses. Two species, BVDV-1 and BVDV-2, discriminated on the basis of genetic and antigenic differences, are classified in the genus Pestivirus within the Flaviviridae family and distributed on all of the continents. BVDV-1 can be segregated into at least twenty-one subgenotypes (1a-1u), while four subgenotypes have been described for BVDV-2 (2a-2d). With respect to published sequences, the number of virus isolates described for BVDV-1 (88.2%) is considerably higher than for BVDV-2 (11.8%). The most frequently-reported BVDV-1 subgenotype are 1b, followed by 1a and 1c. The highest number of various BVDV subgenotypes has been documented in European countries, indicating greater genetic diversity of the virus on this continent. Current segregation of BVDV field isolates and the designation of subgenotypes are not harmonized. While the species BVDV-1 and BVDV-2 can be clearly differentiated independently from the portion of the genome being compared, analysis of different genomic regions can result in inconsistent assignment of some BVDV isolates to defined subgenotypes. To avoid non-conformities the authors recommend the development of a harmonized system for subdivision of BVDV isolates into defined subgenotypes.eninfo:eu-repo/semantics/openAccessVirologyBovine viral diarrhea virusEpidemiologyGlobal distributionGenetic diversitySubgenotypingRuminant pestivirus strainsBorder disease virusGenetic diversiyPhylogenetic analysisMolecular characterizationAntigenic characterizationHomologous recombinationRna recombinationNorthern irelandMucosal diseaseAnimalsCattleCattle diseasesDiarrhea viruses, bovine viralGenetic variationGenome, viralGenotypeGenotyping techniquesGlobal healthPestivirus infectionsReview0004058320000042-s2.0-850196534749628587150VirologyBovine Viral Diarrhea Viruses; Pestivirus; CattleRNA polymeraseVirus RNA5' untranslated regionBovineBovine viral diarrheaBovine viral diarrhea virus 1Bovine viral diarrhea virus 2Genetic variabilityGenotypeNonhumanNucleotide sequenceOpen reading framePhylogenetic treeReviewRNA recombinationUntranslated regionVirus genomeAnimalCattle diseaseClassificationGenetic variationGeneticsGenotyping techniqueGlobal healthPestivirusPestivirus infectionVeterinaryVirology