Yılmaz, YusufYönal, OyaKurt, RamazanÇelikel, Çiğdem AtaiziÖzdoğan, Osman Cavitİmeryüz, NeşeAvşar, ErolKalaycı, Cem2022-07-052022-07-052010-11Yılmaz, Y. vd. (2010). "Serum fetuin A/α2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: Relation with liver fibrosis". Annals of Clinical Biochemistry, 47(Part 6), 549-553.0004-5632https://doi.org/10.1258/acb.2010.010169https://journals.sagepub.com/doi/full/10.1258/acb.2010.010169http://hdl.handle.net/11452/27731Background: Serum concentrations of fetuin A/alpha 2HS-glycoprotein (AHSG) have been linked to human metabolic alterations and can serve as an indicator of liver cell function. We assayed serum levels of AHSG in patients with non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, and examined their association with clinical, biochemical and histological phenotypes. Methods: Serum AHSG levels were determined by enzyme linked immunosorbent assay in 99 patients with biopsy-proven NAFLD and 75 age- and gender-matched controls. Results: Serum AHSG levels were significantly higher in patients with NAFLD (940 +/- 120 mu g/mL) compared with healthy controls (800 +/- 130 mu g/mL, Student's t test, P < 0.001). Bivariate analyses (Spearman's rank correlation) in patients with NAFLD showed a statistically significant association between AHSG levels and insulin resistance as assessed by the HOMA (homeostasis model assessment) index (r = 0.31, P < 0.01) and the liver fibrosis score index (r = 0.36, P < 0.001). The association between AHSG and fibrosis remained statistically significant even after adjustment for potential confounders, including the HOMA index ([beta] = 1.65, t = 2.38, P < 0.05). Conclusion: Serum AHSG levels are significantly increased in adult patients with biopsy-proven NAFLD and are associated with insulin resistance. Importantly, our pilot data indicate that serum AHSG levels may identify NAFLD patients with higher fibrosis scores.eninfo:eu-repo/semantics/openAccessChronic kidney-diseaseInsulin-resistanceMetabolic syndromeAssociationObesityGlycoprotein/fetuinAntagonistMechanismsProteinBiopsyMedical laboratory technologyAdultBlood proteinsFatty liverFemaleHumansLiver cirrhosisMaleMiddle agedSerumArticle0002852701000082-s2.0-7844930193154955347Part 620926473Medical laboratory technologyFetuin A; Glycoprotein; Human AHSG ProteinFetuin AAdultArticleCell functionControlled studyDisease associationDisease severityEnzyme linked immunosorbent assayFemaleHumanInsulin resistanceLiver cellLiver fibrosisMajor clinical studyMaleMetabolic syndrome XNonalcoholic fatty liverPriority journal