Tvarijonaviciute, AstaCeron, Jose J.2021-12-152021-12-152011-03-15Tvarijonaviciute, A. vd. (2011). "Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia". Veterinary Immunology and Immunopathology, 140(1-2), 147-151.0165-24271873-2534https://doi.org/10.1016/j.vetimm.2010.11.011https://www.sciencedirect.com/science/article/pii/S0165242710003934http://hdl.handle.net/11452/23268The objective of this study was to evaluate the influence of an experimentally induced acute inflammation on serum adiponectin and insulin-like growth factor 1 (IGF-1) levels in the dog, and to compare their evolution with other well-established acute phase proteins (APPs) such as C-reactive protein (CRP), and haptoglobin (Hp). Therefore levels of adiponectin, IGF-1 and a profile of APPs were measured in healthy dogs after intravenous administration of E. coli LPS (0.02 mg/kg) and compared with dogs injected with saline solution (0.2 mL/kg). Adiponectin and IGF-1 were both decreased in response to endotoxins in the dog. Significant positive correlations were found between adiponectin and IGF-1 (r = 0.31; p < 0.05). Adiponectin had also a significant negative correlation with CRP (r = 0.39; p < 0.05) and Hp (r = -0.27; p < 0.05), whereas IGF-1 had significant negative correlation with CRP (r = -0.52; p < 0.001). The results obtained in the present study indicate that adiponectin and IGF-1 behave as negative acute phase proteins after acute inflammatory stimulus in dogs.eninfo:eu-repo/semantics/closedAccessImmunologyVeterinary sciencesAdiponectinCRPHpDogEndotoxaemiaIGF-1ExpressionInflammationDecreaseCholineInjuryCanis familiarisAdiponectinAnimalsC-reactive proteinDisease models, animalDog diseasesDogsEndotoxemiaEscherichia coliFemaleHaptoglobinsInsulin-like growth factor iLipopolysaccharidesMaleArticle0002883428000182-s2.0-799609886511471511401-221145113ImmunologyVeterinary sciencesAdiponectin Receptors; AdipoRon; HypoadiponectinemiaAcute phase proteinC reactive proteinEscherichia coli endotoxinHaptoglobinLipopolysaccharideSodium chlorideAdiponectinC reactive proteinHaptoglobinLipopolysaccharideSomatomedin CAcute endotoxemiaAnimal experimentArticleControlled studyDogEndotoxemiaEscherichia coliFemaleImmunostimulationInflammationMaleNonhumanProtein blood levelProtein expressionProtein functionProtein synthesisAnimalAnimal diseaseBloodDisease modelDog diseaseEscherichia coliImmunologyMicrobiology