Hranitz, John M.Duell, Meghan E.2022-04-132022-04-132012-12Oruç, H. H. vd. (2012). "Determination of acute oral toxicity of flumethrin in honey bees". Journal of Economic Entomology, 105(6), 1890-1894.0022-0493https://doi.org/10.1603/EC12055https://academic.oup.com/jee/article/105/6/1890/790101?login=truehttp://hdl.handle.net/11452/25763Flumethrin is one of many pesticides used for the control and treatment of varroatosis in honey bees and for the control of mosquitoes and ticks in the environment. For the control of varroatosis, flumethrin is applied to hives formulated as a plastic strip for several weeks. During this time, honey bees are treated topically with flumethrin, and hive products may accumulate the pesticide. Honey bees may indirectly ingest flumethrin through hygienic behaviors during the application period and receive low doses of flumethrin through comb wax remodeling after the application period. The goal of our study was to determine the acute oral toxicity of flumethrin and observe the acute effects on motor coordination in honey bees (Apis mellifera anatoliaca). Six doses (between 0.125 and 4.000 mu g per bee) in a geometric series were studied. The acute oral LD50 of flumethrin was determined to be 0.527 and 0.178 mu g per bee (n = 210, 95% CI) for 24 and 48 h, respectively. Orally administered flumethrin is highly toxic to honey bees. Oral flumethrin disrupted the motor coordination of honey bees. Honey bees that ingested flumethrin exhibited convulsions in the antennae, legs, and wings at low doses. At higher doses, partial and total paralysis in the antennae, legs, wings, proboscises, bodies, and twitches in the antennae and legs were observed.eninfo:eu-repo/semantics/openAccessEntomologyApis mellifera anatoliacaFlumethrinOralAcute toxicityVarroa-jacobsoni acariApis-melliferaHymenopteraPesticidesApidaeInsecticidesResiduesApis melliferaApis mellifera anatoliacaApoideaIxodidaAdministration, oralAnimalsBeesLethal dose 50PesticidesPyrethrinsArticle0003124456000032-s2.0-8487140492718901894105623356050EntomologyAmitraz; Apiaries; HoneyFlumethrinPesticidePyrethroidAnimalArticleBeeDrug effectLd 50Oral drug administration