Dimas, Konstantinosİkitimur, Elif İlkay2021-10-272021-10-272011-10Ulukaya, E. vd. (2011). “Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo”. European Journal of Medicinal Chemistry, 46(10), 4957-4963.0223-52341768-3254https://doi.org/10.1016/j.ejmech.2011.07.055https://www.sciencedirect.com/science/article/pii/S022352341100568Xhttp://hdl.handle.net/11452/22503Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC50 values were 0.09 mu M for MDA-MB-231 and 3.05 mu M for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment.eninfo:eu-repo/semantics/closedAccessPharmacology & pharmacyPalladium(II) complexBreast cancerCytotoxicityApoptosisTreatmentPlatinum(ıı) complexesBiological evaluationCytotoxic activityPd(ıı)Pt(ıı)AssayMttAnimalsAntineoplastic agentsApoptosisBreast neoplasmsCell line, tumorCoordination complexesFemaleHumansMiceMice, inbred BALB CPalladiumArticle0002960416000182-s2.0-8005317776549574963461021885165Chemistry, medicinalBenzisothiazole; Palladium; 2-PhenylpyridineCisplatinDeath receptor 4Death receptor 5MatrigelPaclitaxelPalladium complexPyridine derivativeSaccharin sodiumAnimal experimentAntineoplastic activityApoptosisArticleBreast cancerCancer cell cultureCancer inhibitionCancer invasionCancer therapyCell deathCell strain mcf 7Controlled studyDrug efficacyDrug mechanismDrug synthesisFemaleHumanHuman cellIc 50In vitro studyIn vivo studyMouseNonhuman