Yılmaz, Sunde SüslüerBüyükgüngör, Orhan2022-09-132022-09-132014-01Yılmaz, V. T. vd. (2014). "Di- and polynuclear silver(I) saccharinate complexes of tertiary diphosphane ligands: Synthesis, structures, in vitro DNA binding, and antibacterial and anticancer properties". Journal of Biological Inorganic Chemistry, 19(1), 29-44.0949-82571432-1327https://doi.org/10.1007/s00775-013-1052-yhttps://link.springer.com/article/10.1007/s00775-013-1052-yhttp://hdl.handle.net/11452/28666A series of new silver(I) saccharinate (sac) complexes, [Ag-2(sac)(2)(mu-dppm)H2O]center dot H2O (1), {[Ag-2(mu-sac)(2)(mu-dppe)]center dot 3H(2)O center dot CH2Cl2} (n) (2), [Ag-2(mu-sac)(2)(mu-dppp)] (n) (3), and [Ag(sac)(mu-dppb)] (n) (4) [dppm is 1,1-bis(diphenylphosphino)methane, dppe is 1,2-bis(diphenylphosphino)ethane, dppp is 1,3-bis(diphenylphosphino)propane, and dppb is 1,4-bis(diphenylphosphino)butane], have been synthesized and characterized by C, H, N elemental analysis, IR spectroscopy, H-1 NMR, C-13 NMR, and P-31 NMR spectroscopy, electrospray ionization mass spectrometry, and thermogravimetry-differential thermal analysis. Single-crystal X-ray studies show that the diphosphanes act as bridging ligands to yield a dinuclear complex (1) and one-dimensional coordination polymers (2 and 4), whereas the sac ligand adopts a mu(2)-N/O bridging mode in 2, and is N-coordinated in 1 and 4. The interaction of the silver(I) complexes with fish sperm DNA was investigated using UV-vis spectroscopy, fluorescence spectroscopy, and agarose gel electrophoresis. The binding studies indicate that the silver(I) complexes can interact with fish sperm DNA through intercalation, and complexes 1 and 3 have the highest binding affinity. The gel electrophoresis assay further confirms the binding of the complexes with the pBR322 plasmid DNA. The minimum inhibitory concentrations of the complexes indicate that complex 1 exhibits very high antibacterial activity against standard bacterial strains of Escherichia coli, Salmonella typhimurium, and Staphylococcus aureus, being much higher than those of AgNO3, silver sulfadiazine, ciprofloxacin, and gentamicin. Moreover, complexes 1-3 exhibit very high cytotoxic activity against A549 and MCF-7 cancer cell lines, compared with AgNO3 and cisplatin. The bacterial and cell growth inhibitions of the silver(I) complexes are closely related to their DNA binding affinities.eninfo:eu-repo/semantics/closedAccessSilver(I) complexesSaccharinateTertiary diphosphanesDNA bindingAntibacterial activityMetalmultinuclear moleculesRay crystal-structureAntimicrobial activitiesCoordination polymersThermal analysisPlatinum(II)ComplexesCarboxylate complexesTopical therapyIr-spectraPalladium(II)Biochemistry & molecular biologyChemistryAnti-bacterial agentsAntineoplastic agentsBacteriaBacterial infectionsCell lineCell line, tumorCoordination complexesDNAHumansModels, molecularNeoplasmsPhosphinesZincArticle0003292363000032-s2.0-84891851872294419124132752Biochemistry & molecular biologyChemistry, inorganic & nuclearComplex; Diphenyl Ethers; SilverAntiinfective agentAntineoplastic agentCiprofloxacinCisplatinDNAGentamicinPlasmid DNASilver nitrateSilver saccharinate 1,1 bis(diphenylphosphino)methane complexSilver saccharinate 1,2 bis(diphenylphosphino)ethane complexSilver saccharinate 1,3 bis(diphenylphosphino)propane complexSilver saccharinate 1,4 bis(diphenylphosphino)butane complexSulfadiazine silverUnclassified drugAgar gel electrophoresisAnimal cellAntibacterial activityAntineoplastic activityArticleBacterial growthBacterial strainBinding affinityCell growthCell strain MCF 7Concentration responseControlled studyDifferential scanning calorimetryDrug DNA bindingDrug structureElectrospray mass spectrometryEscherichia coliFishFluorescence spectroscopyGrowth inhibitionHumanHuman cellIn vitro studyInfrared spectroscopyIntercalation complexMaleMinimum inhibitory concentrationNonhumanNuclear magnetic resonance spectroscopyPriority journalSalmonella typhimuriumSpermStaphylococcus aureusThermogravimetryUltraviolet spectroscopyX ray crystallography