Vahaboğlu, HalukCoşkukan, FigenTansel, ÖzlemÖztürk, RecepŞahin, NursuKöksal, İftiharKocazeybek, BekirTatman, Müşerref OtkunLeblebicioğlu, HakanÖzinel, Mehmet AliKorten, VolkanKocagöz, Sesin2021-07-012021-07-012001-07Vahaboğlu, H. vd. (2001). "Clinical importance of extended-spectrum beta-lactamase (PER-1-type)-producing Acinetobacter spp. and Pseudomonas aeruginosa strains". Journal of Medical Microbiology, 50(7), 642-645.0022-2615https://doi.org/10.1099/0022-1317-50-7-642https://www.microbiologyresearch.org/content/journal/jmm/10.1099/0022-1317-50-7-642http://hdl.handle.net/11452/20961Recently, an extended-spectrum beta -lactamase (PER-I) was found to be disseminated among Acinetobacter spp, and Pseudomonas aeruginosa isolates in Turkey. A population-based cohort study was conducted to elucidate predictive mortality factors in patients with nosocomial infections caused by Acinetobacter spp. and P. aeruginosa, with particular reference to PER-1-type extended-spectrum beta -lactamase (ESBL) production. The study group comprised 16 and 21 non-survivors and 82 and 126 survivors in cohorts infected with Acinetobacter and E. aeruginosa, respectively. In the Acinetobacter-infected cohort, nosocomial pneumonia, hypotension and infection with a PER-positive isolate were independent predictors of mortality. In the P. aeruginosa-infected cohort, impaired consciousness, a PER-positive isolate, male sex and (with a negative relative risk) urinary tract infection were independent predictors of death. This study demonstrated the relationship of PER-1-type ESBL-producing Acinetobacter spp. and P. aeruginosa with poor clinical outcome.eninfo:eu-repo/semantics/openAccessMicrobiologyOuter-membraneResistanceBaumanniiAcquisitionPneumoniaMortalityOutbreakArticle0001695343000102-s2.0-003495408564264550711444775Microbiology