2021-12-082021-12-081997-11Tuncel, P. vd. (1997). "Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation". Research in Experimental Medicine, 197(4), 235-241.0300-9130https://doi.org/10.1007/s004330050072https://link.springer.com/article/10.1007%2Fs004330050072http://hdl.handle.net/11452/23063To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.eninfo:eu-repo/semantics/closedAccessResearch & experimental medicineFecal peritonitisConjugated dienesTBARSVitamin ECimetidineFree-radicalsLung injuryAntioxidantsEndotoxemiaTissuesAcidRatAnimalsCimetidineLipid peroxidationLipidsMalePeritonitisRatsRats, wistarThiobarbituric acid reactive substancesVitamin EArticle0000709877000062-s2.0-003078123323524119749440141Medicine, research & experimentalZymosan; Multiple Organ Failure; Amine Oxidase (Copper Containing)Alpha tocopherolCimetidineLipidThiobarbituric acid reactive substanceAnimal experimentAnimal modelAnimal tissueArticleBlood levelControlled studyDug effectKidneyLipid peroxidationLiverLungMaleNonhumanPeritonitisPriority journalRatSubcutaneous drug administration