Bridoux, AlexandreCui, HuadongDyskin, EvgenySchmitzer, Andreea RuxandraMousa, Shaker A.2022-07-072022-07-072010-06-01Bridoux, A. vd. (2010). "Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 20(11), 3394-3398.0960-894X1464-3405https://doi.org/10.1016/j.bmcl.2010.04.011https://www.sciencedirect.com/science/article/pii/S0960894X10004713http://hdl.handle.net/11452/27789Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.eninfo:eu-repo/semantics/closedAccessThyroxineEsterificationSilylationUV-visAngiogenesisNanopharmaceutical technologyExtracelluler segmentCrystal-structureThyhroid-hormoneForce-fieldProteinsPharmacology & pharmacyChemistryAngiogenesis inhibitorsAnimalsChick embryoMiceModels, molecularThyroxineArticle0002777889000432-s2.0-7795329316033943398201120434332Chemistry, medicinalChemistry, organicTetraiodothyroacetic Acid; Thyroid Hormones; Nano-Diamino-TetracAmino acidAngiogenesis inhibitorMatrigelThyroxine derivativeAngiogenesisAnimal experimentArticleChickChorioallantoisControlled studyDrug activityDrug effectDrug synthesisDrug tolerabilityMouseNonhuman