2021-10-072021-10-071999Büyükcoşkun, N. İ. ve Özlük, K. (1999). "Role of intracerebroventricular vasopressin in the development of stress-induced gastric lesions in rats". Physiological Research, 48(6), 451-455.0862-8408http://www.biomed.cas.cz/physiolres/pdf/48/48_451.pdfhttp://hdl.handle.net/11452/22279We investigated whether arginine vasopressin (AVP) has a central influence on the development of gastric mucosal lesions evoked by restraint-cold stress in rats. AVP and vasopressin V-1 receptor antagonist were injected intracerebroventricularly (icv) and the rats were exposed to restraint-cold stress for five hours. After decapitation the stomachs were examined for gastric mucosal lesions which were evaluated according to an ulcer score. Three different doses of AVP and V-1 receptor antagonist were administered in order to investigate the effects of extogenous and endogenous AVP on stress-induced gastric mucosal lesions. The intensity of gastric mucosal lesions was reduced when exogenous AVP was injected intracerebroventricularly. On the other hand, vasopressin V-1 receptor antagonist, which was administered by the same route, augmented gastric mucosal lesions. Our findings indicate that AVP, injected centrally, plays a role in preventing the formation of gastric mucosal lesions induced by stress via a central V-1 receptor.eninfo:eu-repo/semantics/openAccessPhysiologyVasopressinRestraint-cold stressGastric mucosal lesionsVasopressin V-1 receptor antagonistCorticotropin-releasing factorAcid secretionRestraintUlcerAnimalsArginine vasopressinColdFemaleGastric mucosaInjections, intraventricularRatsRats, sprague-dawleyReceptors, vasopressinRestraint, physicalStomach ulcerStressVasoconstrictor agentsArticle0000845298000082-s2.0-003338499645145548610783910PhysiologyStomach; Rats; DamagesArgipressinSodium chlorideVasopressin receptor antagonistAnimal experimentAnimal modelArticleCold stressControlled studyFemaleNonhumanPathogenesisRatScoring systemStomach mucosa lesion