Sezgin, CanfezaVeral, AliKarabulut, BülentGöker, Erdem2022-03-112022-03-112005-05Kurt, E. vd. (2005). "Therapy, outcome and analysis of c-kit expression in patients with extrapulmonary small cell carcinoma". International Journal of Clinical Practice, 59(5), 537-543.1368-5031https://doi.org/10.1111/j.1368-5031.2005.00447.xhttps://onlinelibrary.wiley.com/doi/10.1111/j.1368-5031.2005.00447.xhttps://pubmed.ncbi.nlm.nih.gov/15857349/http://hdl.handle.net/11452/24943In this study, we aimed to investigate the clinicopathological characteristics with special emphasis on c-kit expression and the treatment results of patients with extrapulmonary small cell carcinoma (EPSCC). The medical records of the patients with EPSCC were reviewed, and the data regarding patient and tumour characteristics, treatment and clinical outcome were retrieved and analysed. A total of 28 patients with the diagnosis of EPSCC were identified. There were 19 males and 9 females, with a mean age of 56.5 years. Patients with limited disease (LD) (n = 13) were treated with surgery, chemotherapy (CT) and radiotherapy with different sequences. Patients with extensive disease (ED) (n = 15) were mainly treated with combination CT. The median overall survival was 14.5 months in patients with LD compared to 11 months in those with ED (p = 0.029). Ten patients (36%) showed c-kit overexpression. There was no significant difference between the survival of c-kit-positive and c-kit-negative patients (p = 0.367). In conclusion, our study demonstrates that the prognosis of EPSCC is poor despite currently available treatments. C-kit may be considered as a potential target for novel therapeutical approaches.eninfo:eu-repo/semantics/closedAccessGeneral & internal medicinePharmacology & pharmacyExtrapulmonarySmall cell carcinomaTherapyC-kitSingle-institution experienceLung-cancerProtein expressionPhase-IIChemotherapyBladderOverexpressionPrognosisDiagnosisImatinibAdultAgedCarcinoma, small cellChemotherapy, adjuvantDisease-free survivalFemaleGastrointestinal neoplasmsGene expressionHumansMaleMiddle agedProto-oncogene proteins c-kitRadiotherapy, adjuvantRetrospective studiesTreatment outcomeArticle0002283072000082-s2.0-2714446642053754359515857349Medicine, general & internalPharmacology & pharmacySmall Cell Carcinoma; Neuroendocrine Carcinoma; EsophagusAntineoplastic agentCarboplatinCisplatinCyclophosphamideDoxorubicinEpirubicinEtoposideFluorouracilIfosfamidePaclitaxelStem cell factor receptorTopotecanVincristineStem cell factor receptorAdultAgedArticleCancer survivalClinical articleClinical featureControlled studyDemographyFemaleHistopathologyHumanImmunohistochemistryKaplan meier methodMaleMedical recordPriority journalPrognosisProtein expressionSmall cell carcinomaTreatment outcomeAdjuvant chemotherapyAdjuvant therapyDisease free survivalGastrointestinal tumorGene expressionGeneticsMiddle agedRetrospective studySmall cell carcinoma