2022-01-202022-01-202012Akkoç, A. vd. (2012). "Expression of matrix metalloproteinases in Marek's disease tumours". Avian Biology Research, 5(2), 93-98.1758-15591758-1567https://doi.org/10.3184/175815512X13267015775641https://journals.sagepub.com/doi/10.3184/175815512X13267015775641http://hdl.handle.net/11452/24187Marek's disease is an important lymphoproliferative neoplasm of chickens, caused by oncogenic strains of herpes virus. Visceral lymphomas and invasion of both central nervous tissues and peripheral nerves by lymphoid cells are common findings. Matrix metalloproteinases (MMPs) are a group of enzymes responsible for extracellular matrix degradation and tumour metastases. The localisations of MMPs in tumour cells were evaluated immunohistochemically. As a result, positive reactions for MMP-9 and MMP-2 enzymes were found in the lymphoid tumour cells. These enzymes may take part in the pathogenesis of Marek's disease causing extracellular matrix degradation and metastasis.eninfo:eu-repo/semantics/closedAccessAgricultureZoologyMatrix metalloproteinasesMarek's diseaseImmunohistochemistryLymphoproliferative diseaseChemically-modified tetracyclinesBroiler-chickensVirus-infectionInhibitorsInvasionBrainMetastasisCellsMmp-9Gallus gallusHerpesviridaeArticle0003053218000062-s2.0-84864381482939852Agriculture, dairy & animal scienceOrnithologyZoologyTissue Inhibitor of Metalloproteinase-1; Gelatinase A; Matrix Metalloproteinase InhibitorsGelatinase aGelatinase bMatrix metalloproteinaseAnimal tissueArticleControlled studyExtracellular matrixHerpes virusImmunohistochemistryLymphoproliferative diseaseMarek diseaseMetastasisNonhumanProtein expressionTumor cellVirus carcinogenesisVirus strain